Report for: New Molecular Mechanisms of Estrogen Action and Their Impact on Future Perspectives in Estrogen Therapy

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Chapter title	A structural explanation for ERalpha/ERbeta SERM discrimination.
Chapter number	3
Book title	New Molecular Mechanisms of Estrogen Action and Their Impact on Future Perspectives in Estrogen Therapy
Published in	Ernst Schering Research Foundation workshop, January 2004
DOI	10.1007/978-3-662-05386-7_3
Pubmed ID	15248503
Book ISBNs	978-3-66-205388-1, 978-3-66-205386-7
Authors	G. L. Greene, A. K. Shiau, K. W. Nettles, Greene, G. L., Shiau, A. K., Nettles, K. W.
Abstract	Many NRs have multiple subtypes that possess distinct expression patterns and that regulate distinct target genes. Antagonists generated through the addition of bulky side chains to agonist scaffolds are limited to being antagonistic on one or more subtypes of a particular NR. The passive antagonism mechanism, as revealed in our studies through direct comparison of the two THC-ER LBD complexes, suggests a new approach to achieving NR antagonism. Compounds could be designed to selectively stabilize the inactive conformations of certain NR subtypes and the active conformations of others. Such ligands are likely to exert novel biological and therapeutic effects.

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Mendeley readers

The data shown below were compiled from readership statistics for 1 Mendeley reader of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country	Count	As %
Unknown	1	100%

Demographic breakdown

Readers by professional status	Count	As %
Student > Ph. D. Student	1	100%

Readers by discipline	Count	As %
Unknown	1	100%

Attention Score in Context

This research output has an Altmetric Attention Score of 9. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 December 2020.

All research outputs

#3,783,121

of 23,041,514 outputs

Outputs from Ernst Schering Research Foundation workshop

of 11 outputs

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#12,486

of 133,858 outputs

Outputs of similar age from Ernst Schering Research Foundation workshop

of 1 outputs

Altmetric has tracked 23,041,514 research outputs across all sources so far. Compared to these this one has done well and is in the 83rd percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.

So far Altmetric has tracked 11 research outputs from this source. They receive a mean Attention Score of 3.4. This one scored the same or higher as 10 of them.

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We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them

New Molecular Mechanisms of Estrogen Action and Their Impact on Future Perspectives in Estrogen Therapy

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Attention Score in Context