Chapter title |
Effect of JM-1232(-), a new sedative on central respiratory activity in newborn rats.
|
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Chapter number | 23 |
Book title |
New Frontiers in Respiratory Control
|
Published in |
Advances in experimental medicine and biology, January 2010
|
DOI | 10.1007/978-1-4419-5692-7_23 |
Pubmed ID | |
Book ISBNs |
978-1-4419-5691-0, 978-1-4419-5692-7
|
Authors |
Junya Kuribayashi, Shun-ichi Kuwana, Yuki Hosokawa, Eiki Hatori, Junzo Takeda |
Abstract |
JM-1232(-), a newly manufactured isoindole derivative, shows sedative effect at a lower concentration compared with propofol. In the present study, we analyzed the response of the central respiratory activity to JM-1232(-). The brainstem-spinal cord of a newborn rat was isolated and was continuously superfused with oxygenated artificial cerebrospinal fluid (ACSF). Rhythmic inspiratory burst activity was recorded from C4 spinal ventral root using a glass suction electrode. We measured C4 burst rate and amplitude of integrated C4 activity. After obtaining a control recording, the preparation was superfused with ACSF containing JM-1232(-) at 10, 100 or 500 microM for 10 min. The application of both 10 and 100 microM JM-1232(-) did not decrease C4 burst rate significantly. However, 500 microM JM-1232(-) reduced C4 burst rate. On the contrary, C4 burst amplitude was not affected by the application of JM-1232(-) for 10 min at any concentrations. In conclusion, JM-1232(-) at a low concentration (but presumably higher than hypnotic dose), did not depress the central respiratory activity, whereas at a high concentration depression was seen. |
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