Cell Fusion
Springer New York
Chapter title |
Fusion of Mesenchymal Stem Cells and Islet Cells for Cell Therapy
|
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Chapter number | 7 |
Book title |
Cell Fusion
|
Published in |
Methods in molecular biology, January 2015
|
DOI | 10.1007/978-1-4939-2703-6_7 |
Pubmed ID | |
Book ISBNs |
978-1-4939-2702-9, 978-1-4939-2703-6
|
Authors |
Shoichiro Sumi, Goichi Yanai, Sumi, Shoichiro, Yanai, Goichi |
Abstract |
Auxiliary use of mesenchymal stem/stromal cells (MSCs) to islet transplantation is shown to enhance efficacy. We hypothesized cell fusion of islet cells and MSCs may provide a new cell source with robustness of MSCs and islet cell function. We succeeded electrofusion between dispersed islet cells and MSCs in rats and fused cells sustained beta-cell function in vitro and in vivo, suggesting their possibility of therapeutic application. Here, we describe our method of cell fusion that enabled us to fuse islet cells to MSCs. |
Country | Count | As % |
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Unknown | 4 | 100% |
Readers by professional status | Count | As % |
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Professor | 1 | 25% |
Student > Bachelor | 1 | 25% |
Unknown | 2 | 50% |
Readers by discipline | Count | As % |
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Biochemistry, Genetics and Molecular Biology | 1 | 25% |
Medicine and Dentistry | 1 | 25% |
Unknown | 2 | 50% |