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Targeting the DNA Damage Response for Anti-Cancer Therapy

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Cover of 'Targeting the DNA Damage Response for Anti-Cancer Therapy'

Table of Contents

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    Book Overview
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    Chapter 1 Targeting DNA Repair in Anti-Cancer Treatments
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    Chapter 2 The DNA Damage Response: Roles in Cancer Etiology and Treatment
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    Chapter 3 Control of DNA Replication by ATR
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    Chapter 4 Targeting ATR for Cancer Therapy: Profile and Expectations for ATR Inhibitors
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    Chapter 5 Targeting ATR for Cancer Therapy: ATR-Targeted Drug Candidates
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    Chapter 6 ATM: Its Recruitment, Activation, Signalling and Contribution to Tumour Suppression
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    Chapter 7 Pre-clinical Profile and Expectations for Pharmacological ATM Inhibition
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    Chapter 8 Targeting ATM for Cancer Therapy: Prospects for Drugging ATM
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    Chapter 9 Targeting CHK1 for Cancer Therapy: Rationale, Progress and Prospects
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    Chapter 10 Preclinical Profiles and Contexts for CHK1 and CHK2 Inhibitors
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    Chapter 11 Clinical Development of CHK1 Inhibitors
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    Chapter 12 Established and Emerging Roles of the DNA-Dependent Protein Kinase Catalytic Subunit (DNA-PKcs)
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    Chapter 13 Targeting DNA-PK as a Therapeutic Approach in Oncology
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    Chapter 14 Dbait: A New Concept of DNA Repair Pathways Inhibitor from Bench to Bedside
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    Chapter 15 Alternative Non-homologous End-Joining: Mechanisms and Targeting Strategies in Cancer
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