| Chapter title |
HIV-1 coreceptors and their inhibitors.
|
|---|---|
| Chapter number | 5 |
| Book title |
Chemokines and Viral Infection
|
| Published in |
Current topics in microbiology and immunology, December 2005
|
| DOI | 10.1007/978-3-540-33397-5_5 |
| Pubmed ID | |
| Book ISBNs |
978-3-54-029207-4, 978-3-54-033397-5
|
| Authors |
Ray N, Doms RW, N. Ray, R. W. Doms, Ray, N., Doms, R. W. |
| Abstract |
Entry of human immunodeficiency virus (HIV) into target cells is mediated by the viral Envelope glycoprotein (Env) and its coordinated interaction with a receptor (CD4) and a coreceptor (usually the chemokine receptors CCR5 or CXCR4). This review describes the identification of chemokine receptors as coreceptors for HIV-1 Env-mediated fusion, the determinants of chemokine receptor usage, and the impact of nonfunctional chemokine receptor alleles on HIV-1 resistance and disease progression. Due to the important role of chemokine receptors in HIV-1 entry, inhibitors of these coreceptors are good candidates for blocking entry and development of antiretroviral therapies. We discuss the different CCR5- and CXCR4-based antiretroviral drugs that have been developed thus far, highlighting the most promising drug candidates. Resistance to these coreceptor inhibitors as well as the impact of these drugs on clinical monitoring and treatment are also discussed. |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 13 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 3 | 23% |
| Student > Bachelor | 1 | 8% |
| Student > Postgraduate | 1 | 8% |
| Student > Master | 1 | 8% |
| Unknown | 7 | 54% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 3 | 23% |
| Agricultural and Biological Sciences | 2 | 15% |
| Medicine and Dentistry | 1 | 8% |
| Unknown | 7 | 54% |