The Early Effects of Radiation on DNA

Table of Contents

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   Book Overview
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   Chapter 1 Mechanisms of Radiation Action on DNA in Model Systems - Their Relevance to Cellular DNA
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   Chapter 2 Biophysical Models of Radiation Action - Development of Simulation Codes
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   Chapter 3 Links Between Radiation Track Structure, Radiochemical Species, and Cell Survival
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   Chapter 4 A Kinetic Investigation of the Mechanisms of Radiation-Induced Strand Breakage in DNA Model Systems
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   Chapter 5 Discussion on Interdisciplinary Approach to Radiation Action
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   Chapter 6 Measurement of DNA Double Strand Breaks in Mammalian Cells: Comparison Between Pulsed Field Gel Electrophoresis and Non-Unwinding Filter Elution
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   Chapter 7 A Mouse Lymphoma Line that Undergoes Rapid Interphase Death (Apoptosis) Shows Extreme Sensitivity to Radiation-Induced DNA Double-Strand Breakage
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   Chapter 8 The Influence of Genome Structural Organization on DNA Damage and Repair in Eukaryotic Cells Exposed to Ionizing Radiation
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    Chapter 9 The Lethality of Radiation-Induced DNA Double-Strand Breaks for Radiations of Differing LET
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    Chapter 10 Single-Strand Breaks and Base Damage in DNA of Human White Blood Cells in Full Blood Exposed to Ionizing Radiation Detected at Biologically Relevant Doses
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    Chapter 11 Discussion: Cellular DNA Strand Breakage
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    Chapter 12 The Role of Radiation Induced Charge Migration with DNA: ESR Studies
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    Chapter 13 Early Chemical Events in the Development of Radiation Damage of DNA - Novel Approaches
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    Chapter 14 Initial Sites of One Electron Attachment in DNA
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    Chapter 15 Molecular Orbital Calculations on DNA Base Pairs
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    Chapter 16 Role of Energy and Charge Transfer in DNA Damage by Densely Ionizing Radiation
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    Chapter 17 Early Cemical Events in DNA Damage
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    Chapter 18 Concepts of Microdosimetry and their Applicability to DNA Studies
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    Chapter 19 The Application of Biophysical Models to Cellular DNA Damage
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    Chapter 20 The Application of Chemical Models to Cellular DNA Damage
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    Chapter 21 What Basis for the Development of Radiation-Induced DNA Damage?
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    Chapter 22 Stochastic Methods in Radiation Chemical Kinetics
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    Chapter 23 The Effect of Environment upon DNA Free Radicals
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    Chapter 24 Chemical Reactivity of DNA Radicals - A Reflection of their Redox Properties
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    Chapter 25 Chemical properties of ‘radiation modifiers’ of DNA damage and their radiobiological effects
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    Chapter 26 Transformation Reactions of Two Isomeric OH-Adducts of 2’-Deoxyguanosine
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    Chapter 27 The Rates of the Reaction of Thiols with Radicals Derived from OH Attack on Polymeric Nucleic Acids and on DNA
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    Chapter 28 Radical Chemistry in Crystals, Matrices and in Aqueous Solution. Redox Properties and Proton Transfer Processes.
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    Chapter 29 Models to Link DNA Damage to RBEs for Final Cellular Effects
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    Chapter 30 Repair of DNA Damage and its Effect on RBE - An Experimental Approach
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    Chapter 31 DNA Double-Strand Break Induction in Yeast by Heavy ION Irradiation
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    Chapter 32 The Use of DNA Precipitation Assay for Evaluating DSB Induced by High and Low LET Radiations: Comparison with Sedimentation Results
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    Chapter 33 Discussion of the Session on RBE from Theory to Experiment
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    Chapter 34 The Development of Chemical Damage of DNA in Aqueous Solution
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    Chapter 35 Radical Multiplicity in Radiation-Induced DNA Strand Breaks: Implications for their Chemical Modification
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    Chapter 36 Effect of Dose Modifiers on Radiation-Induced Cellular DNA Damage
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    Chapter 37 Oxygen Enhancement of Radiosensitivity and Nuclear GSH Content
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    Chapter 38 Timescale for Development of DNA Damage
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    Chapter 39 Primary Damage and Fixation of Chromosomal DNA as Probed by Monochromatic Soft X-rays and Low-Energy Neutrons
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    Chapter 40 Chromosomal Damage in Human Lymphocytes: Effect of Radiation Quality
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    Chapter 41 Heavy-Ion Induced Chromatin Damage and Repair: PCC and Chromosome Painting
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    Chapter 42 Discussion Session on LET and Chromosome Damage
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    Chapter 43 Radical Oxidation of the Purine Moities of DNA and Related Nucleosides
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    Chapter 44 Radical-Induced Base Damage in Aqueous DNA Solutions
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    Chapter 45 Primary and Secondary Radicals in Thymine Derivatives: Solid State ESR/ENDOR Study of 1-Me-Thymine and Thymidine
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    Chapter 46 Radiation Effects on Transcription in Cells and Isolated Cell Nuclei
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    Chapter 47 Summary Comments from a Physicist
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    Chapter 48 Summary from a Chemist’s Point of View
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    Chapter 49 Summary of the Workshop from the View of a Biologist