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Developments in Statistical Evaluation of Clinical Trials

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Table of Contents

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    Book Overview
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    Chapter 1 Statistical Models and Methods for Incomplete Data in Randomized Clinical Trials
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    Chapter 2 Bayesian Decision Theory and the Design and Analysis of Randomized Clinical Trials
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    Chapter 3 Designing Multi-arm Multi-stage Clinical Studies
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    Chapter 4 Statistical Approaches to Improving Trial Efficiency and Conduct
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    Chapter 5 Competing Risks and Survival Analysis
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    Chapter 6 Recent Developments in Group-Sequential Designs
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    Chapter 7 Statistical Inference for Non-inferiority of a Diagnostic Procedure Compared to an Alternative Procedure, Based on the Difference in Correlated Proportions from Multiple Raters
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    Chapter 8 Design and Analysis of Clinical Trial Simulations
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    Chapter 9 Causal Effect Estimation and Dose Adjustment in Exposure-Response Relationship Analysis
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    Chapter 10 Different Methods to Analyse the Results of a Randomized Controlled Trial with More Than One Follow-Up Measurement
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    Chapter 11 Statistical Methods for the Assessment of Clinical Relevance
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    Chapter 12 Statistical Considerations in the Use of Composite Endpoints in Time to Event Analyses
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    Chapter 13 Statistical Validation of Surrogate Markers in Clinical Trials
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    Chapter 14 Biomarker-Based Designs of Phase III Clinical Trials for Personalized Medicine
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    Chapter 15 Dose-Finding Methods for Two-Agent Combination Phase I Trials
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    Chapter 16 Multi-state Models Used in Oncology Trials
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    Chapter 17 Review of Designs for Accommodating Patients’ or Physicians’ Preferences in Randomized Controlled Trials
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    Chapter 18 Dose Finding Methods in Oncology: From the Maximum Tolerated Dose to the Recommended Phase II Dose
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