Chapter title |
Mechanisms and impact of enteric infections.
|
---|---|
Chapter number | 8 |
Book title |
Mechanisms in the Pathogenesis of Enteric Diseases 2
|
Published in |
Advances in experimental medicine and biology, January 1999
|
DOI | 10.1007/978-1-4615-4143-1_8 |
Pubmed ID | |
Book ISBNs |
978-1-4613-6858-8, 978-1-4615-4143-1
|
Authors |
Guerrant, R L, Lima, A A, Barboza, M, Young, S, Silva, T, Barrett, L, Bao, Y, Fox, J, Moore, S, Richard L. Guerrant, Aldo A. M. Lima, Manuel Barboza, Sharon Young, Terezinha Silva, Leah Barrett, Yongde Bao, Jay Fox, Sean Moore, Guerrant, Richard L., Lima, Aldo A. M., Barboza, Manuel, Young, Sharon, Silva, Terezinha, Barrett, Leah, Bao, Yongde, Fox, Jay, Moore, Sean |
Abstract |
The increased recognition of both old and new enteric pathogens and their potential impact requires an improved understanding of pathogenesis and effective interventions. While the overwhelming mortality (> 3 million children per year) due to diarrheal diseases is well-recognized, the potential long-term impacts of enteric infections and early childhood diarrhea morbidity are just beginning to be appreciated. Furthermore, several enteric infections are now being recognized as causes of growth shortfalls with or without diarrhea; i.e., malnutrition may be one of the greatest yet of the "emerging infectious diseases." The increased appreciation of this extended impact calls for further quantification and improved understanding of the deranged physiology. In particular, persistent diarrheal illnesses exhibit common themes of blunted villi, disruption of intestinal barrier function and varying degrees of sub-mucosal inflammation for which lactulose/mannitol permeability and fecal lactoferrin provide respective quantification. Finally, such improved understanding will allow targeted interventions among those most vulnerable, which will enable further documentation of cost effectiveness and the potential for improved human development which is critical to reducing the widening disparity and population overgrowth which increasingly threaten our global security. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
France | 1 | 6% |
Unknown | 17 | 94% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 5 | 28% |
Student > Bachelor | 2 | 11% |
Professor > Associate Professor | 2 | 11% |
Student > Ph. D. Student | 2 | 11% |
Student > Doctoral Student | 1 | 6% |
Other | 3 | 17% |
Unknown | 3 | 17% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 4 | 22% |
Medicine and Dentistry | 3 | 17% |
Biochemistry, Genetics and Molecular Biology | 2 | 11% |
Immunology and Microbiology | 2 | 11% |
Nursing and Health Professions | 1 | 6% |
Other | 3 | 17% |
Unknown | 3 | 17% |