Chapter title |
Tumor-Targeting Therapy Using Gene-Engineered Anaerobic-Nonpathogenic Bifidobacterium longum.
|
---|---|
Chapter number | 5 |
Book title |
Bacterial Therapy of Cancer
|
Published in |
Methods in molecular biology, January 2016
|
DOI | 10.1007/978-1-4939-3515-4_5 |
Pubmed ID | |
Book ISBNs |
978-1-4939-3513-0, 978-1-4939-3515-4
|
Authors |
Taniguchi, Shun'ichiro, Shimatani, Yuko, Fujimori, Minoru, Shun’ichiro Taniguchi, Yuko Shimatani, Minoru Fujimori |
Abstract |
Despite great progress in molecular-targeting drugs for cancer treatment, there are problems of disease recurrence due to cancer-cell resistance to those drugs, derived from the heterogeneity of tumors. On one hand, the low-oxygen microenvironment present in malignant tumor tissues has been regarded as a source of resistance of cancer cells against conventional therapie, such as radiation and chemotherapy. To overcome these problems, we have been developing a system to selectively deliver a large amount of anticancer drugs to malignant tumors by making use of the limiting factor, hypoxia, in tumors. Our strategy is to use hypoxia as a selective target. Here, we show methods and protocols using the nonpathogenic obligate anaerobic Bifidobacterium longum as a drug-delivery system (DDS) to target anaerobic tumor tissue. |
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Mendeley readers
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Student > Bachelor | 5 | 26% |
Student > Master | 2 | 11% |
Unspecified | 1 | 5% |
Professor | 1 | 5% |
Lecturer | 1 | 5% |
Other | 2 | 11% |
Unknown | 7 | 37% |
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Biochemistry, Genetics and Molecular Biology | 4 | 21% |
Medicine and Dentistry | 4 | 21% |
Environmental Science | 1 | 5% |
Chemistry | 1 | 5% |
Unspecified | 1 | 5% |
Other | 0 | 0% |
Unknown | 8 | 42% |