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Bacterial Therapy of Cancer

Overview of attention for book
Cover of 'Bacterial Therapy of Cancer'

Table of Contents

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    Book Overview
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    Chapter 1 Tumor-Targeting Salmonella typhimurium A1-R: An Overview.
  3. Altmetric Badge
    Chapter 2 Enhancement of Tumor-Targeted Delivery of Bacteria with Nitroglycerin Involving Augmentation of the EPR Effect
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    Chapter 3 Oral Delivery of Tumor-Targeting Salmonella to Treat Cancer in Mice
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    Chapter 4 Microfluidic Device to Quantify the Behavior of Therapeutic Bacteria in Three-Dimensional Tumor Tissue.
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    Chapter 5 Tumor-Targeting Therapy Using Gene-Engineered Anaerobic-Nonpathogenic Bifidobacterium longum.
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    Chapter 6 Noninvasive In Vivo Imaging to Follow Bacteria Engaged in Cancer Therapy
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    Chapter 7 In Vivo Bioluminescence Imaging of Intratumoral Bacteria
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    Chapter 8 Employment of Salmonella in Cancer Gene Therapy
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    Chapter 9 Development of a Targeted Gene-Delivery System Using Escherichia coli
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    Chapter 10 Isolation and Analysis of Suppressor Mutations in Tumor-Targeted msbB Salmonella
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    Chapter 11 Determination of Plasmid Segregational Stability in a Growing Bacterial Population
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    Chapter 12 Visualization of Anticancer Salmonella typhimurium Engineered for Remote Control of Therapeutic Proteins
  14. Altmetric Badge
    Chapter 13 Methods for Tumor Targeting with Salmonella typhimurium A1-R.
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    Chapter 14 Salmonella typhimurium A1-R and Cell-Cycle Decoy Therapy of Cancer.
  16. Altmetric Badge
    Chapter 15 Future of Bacterial Therapy of Cancer
Attention for Chapter 14: Salmonella typhimurium A1-R and Cell-Cycle Decoy Therapy of Cancer.
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Chapter title
Salmonella typhimurium A1-R and Cell-Cycle Decoy Therapy of Cancer.
Chapter number 14
Book title
Bacterial Therapy of Cancer
Published in
Methods in molecular biology, January 2016
DOI 10.1007/978-1-4939-3515-4_14
Pubmed ID
Book ISBNs
978-1-4939-3513-0, 978-1-4939-3515-4
Authors

Hoffman, Robert M, Yano, Shuya, Robert M. Hoffman, Shuya Yano

Abstract

Cancer cells in G0/G1 are resistant to cytotoxic chemotherapy agents which kill only cycling cancer cells. Salmonella typhimurium A1-R (S. typhimurium A1-R) decoyed cancer cells in monolayer culture and in tumor spheres to cycle from G0/G1 to S/G2/M, as demonstrated by fluorescence ubiquitination-based cell cycle indicator (FUCCI) imaging. S. typhimurium A1-R targeted FUCCI-expressing subcutaneous tumors, and tumors growing on the liver, growing in nude mice and also decoyed quiescent cancer cells, which were the majority of the cells in the tumors, to cycle from G0/G1 to S/G2/M. The S. typhimurium A1-R-decoyed cancer cells became sensitive to cytotoxic agents.

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X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 11 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 11 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 3 27%
Student > Master 3 27%
Researcher 1 9%
Student > Ph. D. Student 1 9%
Unknown 3 27%
Readers by discipline Count As %
Immunology and Microbiology 2 18%
Engineering 2 18%
Medicine and Dentistry 2 18%
Biochemistry, Genetics and Molecular Biology 1 9%
Environmental Science 1 9%
Other 0 0%
Unknown 3 27%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 February 2016.
All research outputs
#20,305,223
of 22,844,985 outputs
Outputs from Methods in molecular biology
#9,917
of 13,127 outputs
Outputs of similar age
#330,614
of 393,571 outputs
Outputs of similar age from Methods in molecular biology
#1,053
of 1,470 outputs
Altmetric has tracked 22,844,985 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 13,127 research outputs from this source. They receive a mean Attention Score of 3.4. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 393,571 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 1,470 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.