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Bacterial Therapy of Cancer

Overview of attention for book
Cover of 'Bacterial Therapy of Cancer'

Table of Contents

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    Book Overview
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    Chapter 1 Tumor-Targeting Salmonella typhimurium A1-R: An Overview.
  3. Altmetric Badge
    Chapter 2 Enhancement of Tumor-Targeted Delivery of Bacteria with Nitroglycerin Involving Augmentation of the EPR Effect
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    Chapter 3 Oral Delivery of Tumor-Targeting Salmonella to Treat Cancer in Mice
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    Chapter 4 Microfluidic Device to Quantify the Behavior of Therapeutic Bacteria in Three-Dimensional Tumor Tissue.
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    Chapter 5 Tumor-Targeting Therapy Using Gene-Engineered Anaerobic-Nonpathogenic Bifidobacterium longum.
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    Chapter 6 Noninvasive In Vivo Imaging to Follow Bacteria Engaged in Cancer Therapy
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    Chapter 7 In Vivo Bioluminescence Imaging of Intratumoral Bacteria
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    Chapter 8 Employment of Salmonella in Cancer Gene Therapy
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    Chapter 9 Development of a Targeted Gene-Delivery System Using Escherichia coli
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    Chapter 10 Isolation and Analysis of Suppressor Mutations in Tumor-Targeted msbB Salmonella
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    Chapter 11 Determination of Plasmid Segregational Stability in a Growing Bacterial Population
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    Chapter 12 Visualization of Anticancer Salmonella typhimurium Engineered for Remote Control of Therapeutic Proteins
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    Chapter 13 Methods for Tumor Targeting with Salmonella typhimurium A1-R.
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    Chapter 14 Salmonella typhimurium A1-R and Cell-Cycle Decoy Therapy of Cancer.
  16. Altmetric Badge
    Chapter 15 Future of Bacterial Therapy of Cancer
Attention for Chapter 13: Methods for Tumor Targeting with Salmonella typhimurium A1-R.
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  • Above-average Attention Score compared to outputs of the same age and source (64th percentile)

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Citations

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Chapter title
Methods for Tumor Targeting with Salmonella typhimurium A1-R.
Chapter number 13
Book title
Bacterial Therapy of Cancer
Published in
Methods in molecular biology, January 2016
DOI 10.1007/978-1-4939-3515-4_13
Pubmed ID
Book ISBNs
978-1-4939-3513-0, 978-1-4939-3515-4
Authors

Hoffman, Robert M, Zhao, Ming, Robert M. Hoffman, Ming Zhao

Abstract

Salmonella typhimurium A1-R (S. typhimurium A1-R) has shown great preclinical promise as a broad-based anti-cancer therapeutic (please see Chapter 1 ). The present chapter describes materials and methods for the preclinical study of S. typhimurium A1-R in clinically-relevant mouse models. Establishment of orthotopic metastatic mouse models of the major cancer types is described, as well as other useful models, for efficacy studies of S. typhimurium A1-R or other tumor-targeting bacteria, as well. Imaging methods are described to visualize GFP-labeled S. typhimurium A1-R, as well as GFP- and/or RFP-labeled cancer cells in vitro and in vivo, which S. typhimurium A1-R targets. The mouse models include metastasis to major organs that are life-threatening to cancer patients including the liver, lung, bone, and brain and how to target these metastases with S. typhimurium A1-R. Various routes of administration of S. typhimurium A1-R are described with the advantages and disadvantages of each. Basic experiments to determine toxic effects of S. typhimurium A1-R are also described. Also described are methodologies for combining S. typhimurium A1-R and chemotherapy. The testing of S. typhimurium A1-R on patient tumors in patient-derived orthotopic xenograft (PDOX) mouse models is also described. The major methodologies described in this chapter should be translatable for clinical studies.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 22 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 22 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 5 23%
Student > Master 4 18%
Student > Bachelor 3 14%
Student > Ph. D. Student 2 9%
Other 1 5%
Other 1 5%
Unknown 6 27%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 4 18%
Immunology and Microbiology 2 9%
Medicine and Dentistry 2 9%
Agricultural and Biological Sciences 2 9%
Pharmacology, Toxicology and Pharmaceutical Science 1 5%
Other 4 18%
Unknown 7 32%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 February 2016.
All research outputs
#13,781,471
of 21,217,760 outputs
Outputs from Methods in molecular biology
#4,168
of 11,936 outputs
Outputs of similar age
#204,280
of 374,167 outputs
Outputs of similar age from Methods in molecular biology
#371
of 1,195 outputs
Altmetric has tracked 21,217,760 research outputs across all sources so far. This one is in the 33rd percentile – i.e., 33% of other outputs scored the same or lower than it.
So far Altmetric has tracked 11,936 research outputs from this source. They receive a mean Attention Score of 3.3. This one has gotten more attention than average, scoring higher than 60% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 374,167 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 42nd percentile – i.e., 42% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 1,195 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 64% of its contemporaries.