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Bacterial Therapy of Cancer

Overview of attention for book
Cover of 'Bacterial Therapy of Cancer'

Table of Contents

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    Book Overview
  2. Altmetric Badge
    Chapter 1 Tumor-Targeting Salmonella typhimurium A1-R: An Overview.
  3. Altmetric Badge
    Chapter 2 Enhancement of Tumor-Targeted Delivery of Bacteria with Nitroglycerin Involving Augmentation of the EPR Effect
  4. Altmetric Badge
    Chapter 3 Oral Delivery of Tumor-Targeting Salmonella to Treat Cancer in Mice
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    Chapter 4 Microfluidic Device to Quantify the Behavior of Therapeutic Bacteria in Three-Dimensional Tumor Tissue.
  6. Altmetric Badge
    Chapter 5 Tumor-Targeting Therapy Using Gene-Engineered Anaerobic-Nonpathogenic Bifidobacterium longum.
  7. Altmetric Badge
    Chapter 6 Noninvasive In Vivo Imaging to Follow Bacteria Engaged in Cancer Therapy
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    Chapter 7 In Vivo Bioluminescence Imaging of Intratumoral Bacteria
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    Chapter 8 Employment of Salmonella in Cancer Gene Therapy
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    Chapter 9 Development of a Targeted Gene-Delivery System Using Escherichia coli
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    Chapter 10 Isolation and Analysis of Suppressor Mutations in Tumor-Targeted msbB Salmonella
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    Chapter 11 Determination of Plasmid Segregational Stability in a Growing Bacterial Population
  13. Altmetric Badge
    Chapter 12 Visualization of Anticancer Salmonella typhimurium Engineered for Remote Control of Therapeutic Proteins
  14. Altmetric Badge
    Chapter 13 Methods for Tumor Targeting with Salmonella typhimurium A1-R.
  15. Altmetric Badge
    Chapter 14 Salmonella typhimurium A1-R and Cell-Cycle Decoy Therapy of Cancer.
  16. Altmetric Badge
    Chapter 15 Future of Bacterial Therapy of Cancer
Attention for Chapter 1: Tumor-Targeting Salmonella typhimurium A1-R: An Overview.
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Chapter title
Tumor-Targeting Salmonella typhimurium A1-R: An Overview.
Chapter number 1
Book title
Bacterial Therapy of Cancer
Published in
Methods in molecular biology, January 2016
DOI 10.1007/978-1-4939-3515-4_1
Pubmed ID
Book ISBNs
978-1-4939-3513-0, 978-1-4939-3515-4
Authors

Hoffman, Robert M, Robert M. Hoffman

Abstract

The present chapter reviews the development of the tumor-targeting amino-acid auxotrophic strain S. typhimurium A1 and the in vivo selection and characterization of the high-tumor-targeting strain S. typhimurium A1-R. Efficacy of S. typhimurium A1-R in nude-mouse models of prostate, breast, pancreatic, and ovarian cancer, as well as sarcoma and glioma in orthotopic mouse models is described. Also reviewed is efficacy of S. typhimurium A1-R targeting of primary bone tumor and lung metastasis of high-grade osteosarcoma, breast-cancer brain metastasis, and experimental breast-cancer bone metastasis in orthotopic mouse models. The efficacy of S. typhimurium A1-R on pancreatic cancer stem cells, on pancreatic cancer in combination with anti-angiogenic agents, as well as on cervical cancer, soft-tissue sarcoma, and pancreatic cancer patient-derived orthotopic xenograft (PDOX) mouse models, is also described.

X Demographics

X Demographics

The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 39 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Germany 1 3%
Unknown 38 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 9 23%
Student > Master 4 10%
Student > Bachelor 4 10%
Researcher 3 8%
Student > Doctoral Student 2 5%
Other 8 21%
Unknown 9 23%
Readers by discipline Count As %
Medicine and Dentistry 9 23%
Biochemistry, Genetics and Molecular Biology 4 10%
Nursing and Health Professions 3 8%
Agricultural and Biological Sciences 3 8%
Engineering 2 5%
Other 4 10%
Unknown 14 36%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 February 2016.
All research outputs
#14,834,028
of 22,844,985 outputs
Outputs from Methods in molecular biology
#4,698
of 13,127 outputs
Outputs of similar age
#218,903
of 393,571 outputs
Outputs of similar age from Methods in molecular biology
#469
of 1,470 outputs
Altmetric has tracked 22,844,985 research outputs across all sources so far. This one is in the 32nd percentile – i.e., 32% of other outputs scored the same or lower than it.
So far Altmetric has tracked 13,127 research outputs from this source. They receive a mean Attention Score of 3.4. This one has gotten more attention than average, scoring higher than 59% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 393,571 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 41st percentile – i.e., 41% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 1,470 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 63% of its contemporaries.