Chapter title |
Tumor-Targeting Salmonella typhimurium A1-R: An Overview.
|
---|---|
Chapter number | 1 |
Book title |
Bacterial Therapy of Cancer
|
Published in |
Methods in molecular biology, January 2016
|
DOI | 10.1007/978-1-4939-3515-4_1 |
Pubmed ID | |
Book ISBNs |
978-1-4939-3513-0, 978-1-4939-3515-4
|
Authors |
Hoffman, Robert M, Robert M. Hoffman |
Abstract |
The present chapter reviews the development of the tumor-targeting amino-acid auxotrophic strain S. typhimurium A1 and the in vivo selection and characterization of the high-tumor-targeting strain S. typhimurium A1-R. Efficacy of S. typhimurium A1-R in nude-mouse models of prostate, breast, pancreatic, and ovarian cancer, as well as sarcoma and glioma in orthotopic mouse models is described. Also reviewed is efficacy of S. typhimurium A1-R targeting of primary bone tumor and lung metastasis of high-grade osteosarcoma, breast-cancer brain metastasis, and experimental breast-cancer bone metastasis in orthotopic mouse models. The efficacy of S. typhimurium A1-R on pancreatic cancer stem cells, on pancreatic cancer in combination with anti-angiogenic agents, as well as on cervical cancer, soft-tissue sarcoma, and pancreatic cancer patient-derived orthotopic xenograft (PDOX) mouse models, is also described. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Portugal | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Germany | 1 | 3% |
Unknown | 38 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 9 | 23% |
Student > Master | 4 | 10% |
Student > Bachelor | 4 | 10% |
Researcher | 3 | 8% |
Student > Doctoral Student | 2 | 5% |
Other | 8 | 21% |
Unknown | 9 | 23% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 9 | 23% |
Biochemistry, Genetics and Molecular Biology | 4 | 10% |
Nursing and Health Professions | 3 | 8% |
Agricultural and Biological Sciences | 3 | 8% |
Engineering | 2 | 5% |
Other | 4 | 10% |
Unknown | 14 | 36% |