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Bacterial Therapy of Cancer

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Cover of 'Bacterial Therapy of Cancer'

Table of Contents

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    Book Overview
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    Chapter 1 Tumor-Targeting Salmonella typhimurium A1-R: An Overview.
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    Chapter 2 Enhancement of Tumor-Targeted Delivery of Bacteria with Nitroglycerin Involving Augmentation of the EPR Effect
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    Chapter 3 Oral Delivery of Tumor-Targeting Salmonella to Treat Cancer in Mice
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    Chapter 4 Microfluidic Device to Quantify the Behavior of Therapeutic Bacteria in Three-Dimensional Tumor Tissue.
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    Chapter 5 Tumor-Targeting Therapy Using Gene-Engineered Anaerobic-Nonpathogenic Bifidobacterium longum.
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    Chapter 6 Noninvasive In Vivo Imaging to Follow Bacteria Engaged in Cancer Therapy
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    Chapter 7 In Vivo Bioluminescence Imaging of Intratumoral Bacteria
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    Chapter 8 Employment of Salmonella in Cancer Gene Therapy
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    Chapter 9 Development of a Targeted Gene-Delivery System Using Escherichia coli
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    Chapter 10 Isolation and Analysis of Suppressor Mutations in Tumor-Targeted msbB Salmonella
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    Chapter 11 Determination of Plasmid Segregational Stability in a Growing Bacterial Population
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    Chapter 12 Visualization of Anticancer Salmonella typhimurium Engineered for Remote Control of Therapeutic Proteins
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    Chapter 13 Methods for Tumor Targeting with Salmonella typhimurium A1-R.
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    Chapter 14 Salmonella typhimurium A1-R and Cell-Cycle Decoy Therapy of Cancer.
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    Chapter 15 Future of Bacterial Therapy of Cancer
Attention for Chapter 15: Future of Bacterial Therapy of Cancer
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Chapter title
Future of Bacterial Therapy of Cancer
Chapter number 15
Book title
Bacterial Therapy of Cancer
Published in
Methods in molecular biology, January 2016
DOI 10.1007/978-1-4939-3515-4_15
Pubmed ID
Book ISBNs
978-1-4939-3513-0, 978-1-4939-3515-4
Authors

Robert M. Hoffman

Abstract

Bacterial therapy of cancer has a centuries-long history and was first-line therapy at the hospital in New York City that would become Memorial Sloan-Kettering Cancer Center, under Dr. William B. Coley. However, after Coley's death in 1936, bacterial therapy of cancer ceased in the clinic until the present century. Clinical trials have been recently carried out for strains of the obligate anaerobe Clostridium novyi with the toxin gene deleted, and on an attenuated strain of Salmonella typhimurium (S. typhimurium), which is a facultative anaerobe that can grow in viable, as well as necrotic, areas of tumors, unlike Clostridium, which can only grow in the hypoxic areas. Our laboratory has developed the novel strain S. typhimurium A1-R that is effective against all tumor types in clinically-relevant mouse models, including patient-derived orthotopic xenograft (PDOX) mouse models. This chapter suggests future clinical applications for S. typhimurium A1-R.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 21 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 21 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 5 24%
Student > Ph. D. Student 4 19%
Student > Postgraduate 3 14%
Professor > Associate Professor 2 10%
Other 1 5%
Other 2 10%
Unknown 4 19%
Readers by discipline Count As %
Medicine and Dentistry 10 48%
Biochemistry, Genetics and Molecular Biology 2 10%
Engineering 2 10%
Agricultural and Biological Sciences 1 5%
Immunology and Microbiology 1 5%
Other 1 5%
Unknown 4 19%