Attention for Chapter 12:
The Non-random Repositioning of Whole Chromosomes and Individual Gene Loci in Interphase Nuclei and Its Relevance in Disease, Infection, Aging, and Cancer.
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About this Attention Score
In the top 25% of all research outputs scored by Altmetric
High Attention Score compared to outputs of the same age (84th percentile)
High Attention Score compared to outputs of the same age and source (87th percentile)
The Non-random Repositioning of Whole Chromosomes and Individual Gene Loci in Interphase Nuclei and Its Relevance in Disease, Infection, Aging, and Cancer.
Chapter number
12
Book title
Cancer Biology and the Nuclear Envelope
Published in
Advances in experimental medicine and biology, January 2014
Bridger JM, Arican-Gotkas HD, Foster HA, Godwin LS, Harvey A, Kill IR, Knight M, Mehta IS, Ahmed MH, Bridger, Joanna M, Arican-Gotkas, Halime D, Foster, Helen A, Godwin, Lauren S, Harvey, Amanda, Kill, Ian R, Knight, Matty, Mehta, Ishita S, Ahmed, Mai Hassan, Bridger, Joanna M., Arican-Gotkas, Halime D., Foster, Helen A., Godwin, Lauren S., Kill, Ian R., Mehta, Ishita S., Joanna M. Bridger, Halime D. Arican-Gotkas, Helen A. Foster, Lauren S. Godwin, Amanda Harvey, Ian R. Kill, Matty Knight, Ishita S. Mehta, Mai Hassan Ahmed
Abstract
The genomes of a wide range of different organisms are non-randomly organized within interphase nuclei. Chromosomes and genes can be moved rapidly, with direction, to new non-random locations within nuclei upon a stimulus such as a signal to initiate differentiation, quiescence or senescence, or also the application of heat or an infection with a pathogen. It is now becoming increasingly obvious that chromosome and gene position can be altered in diseases such as cancer and other syndromes that are affected by changes to nuclear architecture such as the laminopathies. This repositioning seems to affect gene expression in these cells and may play a role in progression of the disease. We have some evidence in breast cancer cells and in the premature aging disease Hutchinson-Gilford Progeria that an aberrant nuclear envelope may lead to genome repositioning and correction of these nuclear envelope defects can restore proper gene positioning and expression in both disease situations.Although spatial positioning of the genome probably does not entirely control expression of genes, it appears that spatio-epigenetics may enhance the control over gene expression globally and/or is deeply involved in regulating specific sets of genes. A deviation from normal spatial positioning of the genome for a particular cell type could lead to changes that affect the future health of the cell or even an individual.
Pharmacology, Toxicology and Pharmaceutical Science
2
7%
Psychology
1
3%
Other
0
0%
Unknown
6
20%
Attention Score in Context
Attention Score in Context
This research output has an Altmetric Attention Score of 8. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 May 2017.
All research outputs
#4,185,043
of 24,037,100 outputs
Outputs from Advances in experimental medicine and biology
#668
of 5,105 outputs
Outputs of similar age
#47,507
of 314,721 outputs
Outputs of similar age from Advances in experimental medicine and biology
#18
of 139 outputs
Altmetric has tracked 24,037,100 research outputs across all sources so far. Compared to these this one has done well and is in the 82nd percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 5,105 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.5. This one has done well, scoring higher than 86% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 314,721 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 84% of its contemporaries.
We're also able to compare this research output to 139 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 87% of its contemporaries.
