Chapter title |
Expression of MHC class I genes in mouse hepatitis virus (MHV-A59) infection and in multiple sclerosis.
|
---|---|
Chapter number | 26 |
Book title |
Coronaviruses
|
Published in |
Advances in experimental medicine and biology, January 1987
|
DOI | 10.1007/978-1-4684-1280-2_26 |
Pubmed ID | |
Book ISBNs |
978-1-4684-1282-6, 978-1-4684-1280-2
|
Authors |
Lavi, E, Suzumura, A, Lampson, L A, Siegel, R M, Murasko, D M, Silberberg, D H, Weiss, S R, Ehud Lavi, Akio Suzumura, Lois A. Lampson, Richard M. Siegel, Donna M. Murasko, Donald H. Silberberg, Susan R. Weiss, Lavi, Ehud, Suzumura, Akio, Lampson, Lois A., Siegel, Richard M., Murasko, Donna M., Silberberg, Donald H., Weiss, Susan R. |
Abstract |
Our studies revealed that virus induced demyelination as well as human inflammatory demyelination involves upregulation of class I MHC genes and surface expression of antigens encoded by these genes. Induction involves the action of an intermediate soluble factor/s which is at present unknown. These findings suggest that MHC class I restricted, cytotoxic T lymphocyte (CTL) reactions, against self or foreign antigens may play a role in these conditions. These findings may help to elucidate the mechanism of coronavirus-induced demyelination as well as the pathogenesis of multiple sclerosis. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 29 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 8 | 28% |
Professor > Associate Professor | 4 | 14% |
Student > Master | 3 | 10% |
Student > Bachelor | 2 | 7% |
Student > Ph. D. Student | 2 | 7% |
Other | 4 | 14% |
Unknown | 6 | 21% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 7 | 24% |
Biochemistry, Genetics and Molecular Biology | 4 | 14% |
Medicine and Dentistry | 4 | 14% |
Environmental Science | 1 | 3% |
Nursing and Health Professions | 1 | 3% |
Other | 3 | 10% |
Unknown | 9 | 31% |