Chapter title |
Neuromedin S: discovery and functions.
|
---|---|
Chapter number | 54 |
Book title |
Orphan G Protein-Coupled Receptors and Novel Neuropeptides
|
Published in |
Results and problems in cell differentiation, January 2008
|
DOI | 10.1007/400_2007_054 |
Pubmed ID | |
Book ISBNs |
978-3-54-078350-3, 978-3-54-078351-0
|
Authors |
Kenji Mori, Mikiya Miyazato, Kenji Kangawa, Mori, Kenji, Miyazato, Mikiya, Kangawa, Kenji |
Abstract |
Neuromedin S, a novel neuropeptide of 36 amino acids, was isolated from rat brain as an endogenous ligand for the orphan G protein-coupled receptors FM-3/GPR66 and FM-4/TGR-1, identified to date as type-1 and type-2 neuromedin U (NMU) receptors, respectively. The peptide was designated neuromedin S (NMS) because it is specifically expressed in the suprachiasmatic nucleus of the hypothalamus. NMS is structurally related to NMU; these peptides share a C-terminal core structure. In this review, we will outline the recent discoveries regarding the structure, cognate receptors, distribution, and possible physiological functions of NMS. |
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