Chapter title |
Designing B-Cell Epitopes for Immunotherapy and Subunit Vaccines
|
---|---|
Chapter number | 28 |
Book title |
Peptide Antibodies
|
Published in |
Methods in molecular biology, January 2015
|
DOI | 10.1007/978-1-4939-2999-3_28 |
Pubmed ID | |
Book ISBNs |
978-1-4939-2998-6, 978-1-4939-2999-3
|
Authors |
Harinder Singh, Sudheer Gupta, Ankur Gautam, Gajendra P. S. Raghava, Singh, Harinder, Gupta, Sudheer, Gautam, Ankur, Raghava, Gajendra P. S. |
Abstract |
Rationally designed subunit vaccines mainly consist of small peptides or B-cell epitopes, which can stimulate the body's immune response. Development of subunit vaccines is a very tedious and costly process. One of the imperative and crucial steps of vaccine development is the identification of highly competent B-cell epitopes as most of the proteins and fragments of proteins are immunologically irrelevant. With the advances in bioinformatics tools, it can be possible to precisely narrow down potential B-cell epitopes from the whole proteome of any pathogen. This chapter sheds light on prediction and designing of B-cell epitopes using two in silico tools LBtope and IgPred. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 14 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 4 | 29% |
Professor > Associate Professor | 2 | 14% |
Student > Master | 2 | 14% |
Student > Doctoral Student | 1 | 7% |
Professor | 1 | 7% |
Other | 3 | 21% |
Unknown | 1 | 7% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 4 | 29% |
Biochemistry, Genetics and Molecular Biology | 2 | 14% |
Immunology and Microbiology | 2 | 14% |
Agricultural and Biological Sciences | 1 | 7% |
Neuroscience | 1 | 7% |
Other | 1 | 7% |
Unknown | 3 | 21% |