↓ Skip to main content

Clinical Applications of Mass Spectrometry in Drug Analysis

Overview of attention for book
Cover of 'Clinical Applications of Mass Spectrometry in Drug Analysis'

Table of Contents

  1. Altmetric Badge
    Book Overview
  2. Altmetric Badge
    Chapter 1 Mass Spectrometry in Clinical Laboratory: Applications in Therapeutic Drug Monitoring and Toxicology.
  3. Altmetric Badge
    Chapter 2 Quantitation of Flecainide, Mexiletine, Propafenone, and Amiodarone in Serum or Plasma Using Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)
  4. Altmetric Badge
    Chapter 3 Quantitation of the Oral Anticoagulants Dabigatran, Rivaroxaban, Apixaban, and Warfarin in Plasma Using Ultra-Performance Liquid Chromatography with Tandem Mass Spectrometry (UPLC-MS/MS)
  5. Altmetric Badge
    Chapter 4 Simultaneous Quantitation of Lamotrigine, Levetiracetam, 10-Hydroxycarbazepine, Topiramate, and Zonisamide in Serum Using HPLC-MS/MS
  6. Altmetric Badge
    Chapter 5 Quantification of the Triazole Antifungal Compounds Voriconazole and Posaconazole in Human Serum or Plasma Using Liquid Chromatography Electrospray Tandem Mass Spectrometry (HPLC-ESI-MS/MS)
  7. Altmetric Badge
    Chapter 6 Quantitation of Haloperidol, Fluphenazine, Perphenazine, and Thiothixene in Serum or Plasma Using Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)
  8. Altmetric Badge
    Chapter 7 Quantitation of Total Buprenorphine and Norbuprenorphine in Meconium by LC-MS/MS
  9. Altmetric Badge
    Chapter 8 Quantitation of Buprenorphine, Norbuprenorphine, Buprenorphine Glucuronide, Norbuprenorphine Glucuronide, and Naloxone in Urine by LC-MS/MS
  10. Altmetric Badge
    Chapter 9 A Simple Liquid Chromatography Tandem Mass Spectrometry Method for Quantitation of Plasma Busulfan
  11. Altmetric Badge
    Chapter 10 High-Throughput Quantitation of Busulfan in Plasma Using Ultrafast Solid-Phase Extraction Tandem Mass Spectrometry (SPE-MS/MS)
  12. Altmetric Badge
    Chapter 11 Quantification of 11-Carboxy-Delta-9-Tetrahydrocannabinol (THC-COOH) in Meconium Using Gas Chromatography/Mass Spectrometry (GC/MS)
  13. Altmetric Badge
    Chapter 12 Quantitation of Carisoprodol and Meprobamate in Urine and Plasma Using Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)
  14. Altmetric Badge
    Chapter 13 Cetirizine Quantification by High-Performance Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS)
  15. Altmetric Badge
    Chapter 14 Quantification of Docetaxel in Serum Using Turbulent Flow Liquid Chromatography Electrospray Tandem Mass Spectrometry (TFC-HPLC-ESI-MS/MS)
  16. Altmetric Badge
    Chapter 15 Comprehensive Urine Drug Screen by Gas Chromatography/Mass Spectrometry (GC/MS)
  17. Altmetric Badge
    Chapter 16 Broad-Spectrum Drug Screening Using Liquid Chromatography-Hybrid Triple-Quadrupole Linear Ion Trap Mass Spectrometry
  18. Altmetric Badge
    Chapter 17 High-Resolution Mass Spectrometry for Untargeted Drug Screening
  19. Altmetric Badge
    Chapter 18 Quantitation of Ethyl Glucuronide and Ethyl Sulfate in Urine Using Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)
  20. Altmetric Badge
    Chapter 19 Quantification of Hydroxychloroquine in Blood Using Turbulent Flow Liquid Chromatography-Tandem Mass Spectrometry (TFLC-MS/MS)
  21. Altmetric Badge
    Chapter 20 Quantification of Iohexol in Serum by High-Performance Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)
  22. Altmetric Badge
    Chapter 21 Quantitation of Teriflunomide in Human Serum/Plasma Across a 40,000-Fold Concentration Range by LC/MS/MS.
  23. Altmetric Badge
    Chapter 22 Determination of Menthol in Plasma and Urine by Gas Chromatography/Mass Spectrometry (GC/MS)
  24. Altmetric Badge
    Chapter 23 Development of an Assay for Methotrexate and Its Metabolites 7-Hydroxy Methotrexate and DAMPA in Serum by LC-MS/MS
  25. Altmetric Badge
    Chapter 24 Quantitative, Multidrug Pain Medication Testing by Liquid Chromatography: Tandem Mass Spectrometry (LC-MS/MS)
  26. Altmetric Badge
    Chapter 25 Quantification of Free Phenytoin by Liquid Chromatography Tandem Mass Spectrometry (LC/MS/MS)
  27. Altmetric Badge
    Chapter 26 Detection of Stimulants and Narcotics by Liquid Chromatography-Tandem Mass Spectrometry and Gas Chromatography-Mass Spectrometry for Sports Doping Control
  28. Altmetric Badge
    Chapter 27 Quantification of Tricyclic Antidepressants in Serum Using Liquid Chromatography Electrospray Tandem Mass Spectrometry (HPLC-ESI-MS/MS)
Attention for Chapter 19: Quantification of Hydroxychloroquine in Blood Using Turbulent Flow Liquid Chromatography-Tandem Mass Spectrometry (TFLC-MS/MS)
Altmetric Badge

Citations

dimensions_citation
12 Dimensions

Readers on

mendeley
9 Mendeley
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Chapter title
Quantification of Hydroxychloroquine in Blood Using Turbulent Flow Liquid Chromatography-Tandem Mass Spectrometry (TFLC-MS/MS)
Chapter number 19
Book title
Clinical Applications of Mass Spectrometry in Drug Analysis
Published in
Methods in molecular biology, January 2016
DOI 10.1007/978-1-4939-3252-8_19
Pubmed ID
Book ISBNs
978-1-4939-3251-1, 978-1-4939-3252-8
Authors

Allison B. Chambliss, Anna K. Füzéry, William A. Clarke

Abstract

Hydroxychloroquine (HQ) is used routinely in the treatment of autoimmune disorders such as rheumatoid arthritis and lupus erythematosus. Issues such as marked pharmacokinetic variability and patient non-compliance make therapeutic drug monitoring of HQ a useful tool for management of patients taking this drug. Quantitative measurements of HQ may aid in identifying poor efficacy as well as provide reliable information to distinguish patient non-compliance from refractory disease. We describe a rapid 7-min assay for the accurate and precise measurement of HQ concentrations in 100 μL samples of human blood using turbulent flow liquid chromatography coupled to tandem mass spectrometry. HQ is isolated from EDTA whole blood after a simple extraction with its deuterated analog, hydroxychloroquine-d4, in 0.33 M perchloric acid. Samples are then centrifuged and injected onto the TFLC-MS/MS system. Quantification is performed using a nine-point calibration curve that is linear over a wide range (15.7-4000 ng/mL) with precisions of <5 %.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 9 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 11%
Unknown 8 89%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 2 22%
Researcher 2 22%
Other 1 11%
Student > Doctoral Student 1 11%
Unknown 3 33%
Readers by discipline Count As %
Neuroscience 2 22%
Agricultural and Biological Sciences 1 11%
Biochemistry, Genetics and Molecular Biology 1 11%
Medicine and Dentistry 1 11%
Computer Science 1 11%
Other 0 0%
Unknown 3 33%