Chapter title |
Quantitation of Flecainide, Mexiletine, Propafenone, and Amiodarone in Serum or Plasma Using Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)
|
---|---|
Chapter number | 2 |
Book title |
Clinical Applications of Mass Spectrometry in Drug Analysis
|
Published in |
Methods in molecular biology, January 2016
|
DOI | 10.1007/978-1-4939-3252-8_2 |
Pubmed ID | |
Book ISBNs |
978-1-4939-3251-1, 978-1-4939-3252-8
|
Authors |
Matthew H. Slawson, Kamisha L. Johnson-Davis |
Abstract |
Flecainide, mexiletine, propafenone, and amiodarone are antiarrhythmic drugs that are used primarily in the treatment of cardiac arrhythmias. The monitoring of the use of these drugs has applications in therapeutic drug monitoring and overdose situations. LC-MS/MS is used to analyze plasma/serum extracts with loxapine as the internal standard to ensure accurate quantitation and control for any potential matrix effects. Positive ion electrospray is used to introduce the analytes into the mass spectrometer. Selected reaction monitoring of two product ions for each analyte allows for the calculation of ion ratios which ensures correct identification of each analyte, while a matrix matched calibration curve is used for quantitation. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 19 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 4 | 21% |
Researcher | 4 | 21% |
Other | 3 | 16% |
Student > Ph. D. Student | 2 | 11% |
Student > Doctoral Student | 1 | 5% |
Other | 1 | 5% |
Unknown | 4 | 21% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 4 | 21% |
Medicine and Dentistry | 4 | 21% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 11% |
Chemistry | 2 | 11% |
Social Sciences | 1 | 5% |
Other | 2 | 11% |
Unknown | 4 | 21% |