Chapter title |
Microarray Technology and Its Applications for Detecting Plasma microRNA Biomarkers in Digestive Tract Cancers.
|
---|---|
Chapter number | 8 |
Book title |
Microarray Technology
|
Published in |
Methods in molecular biology, January 2016
|
DOI | 10.1007/978-1-4939-3136-1_8 |
Pubmed ID | |
Book ISBNs |
978-1-4939-3135-4, 978-1-4939-3136-1
|
Authors |
Konishi, Hirotaka, Ichikawa, Daisuke, Arita, Tomohiro, Otsuji, Eigo, Hirotaka Konishi, Daisuke Ichikawa, Tomohiro Arita, Eigo Otsuji |
Abstract |
Many cancers are known to be regulated by microRNAs (miRNAs), and the relationships between tissue miRNA expression levels and the amounts of miRNA circulating in the plasma (or plasma miRNA) have been examined in many types of cancers, including digestive tract cancers. The role of plasma miRNAs has yet to be elucidated in detail; therefore a comprehensive analysis of plasma miRNAs using microarrays should assist in establishing the utility of liquid biopsy or companion diagnosis. We here described the 3D-Gene(®) miRNA microarray (TORAY) currently used in our laboratory and introduced a trial application in digestive tract cancer diagnosis. |
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