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Meningococcal Vaccines

Overview of attention for book
Attention for Chapter: Purification of Capsular Polysaccharide
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Chapter title
Purification of Capsular Polysaccharide
Book title
Meningococcal Vaccines
Published in
Methods in molecular medicine, June 2001
DOI 10.1385/1-59259-148-5:41
Pubmed ID
Book ISBNs
978-1-59259-148-0, 978-0-89603-801-1
Authors

Yang, Qingling, Jennings, Harold, Qingling Yang, Harold Jennings

Abstract

Meningococcus is an aerobic, fastidious, Gram-negative diplococcus that is found only in humans. Its cell wall has a cytoplasmic membrane, a peptidoglycan layer, and an outer membrane. Meningococci isolated from the bloodstream or the spinal fluid are almost always encapsulated. The capsules are polysaccharides, which consist of repeating sugar units (1,2). The capsular polysaccharide can be isolated, purified, and chemically and physically defined. Based on the chemical and immunological specificity of its capsular polysaccharides, Neisseria meningitidis has been classified serologically into groups A, B, C, 29E, H, I, K, L, W135, X, Y and Z (2). Of these, groups A, B, and C are responsible for approx 90% of meningococcal meningitis, and group B meningococcus is responsible for the majority of meningococcal disease in industrialized countries (1,2). The structures of the repeating units of the meningococcal polysaccharides have been elucidated and are shown in Table 1. Table 1 Structures of the Capsular Polysaccharides of N. meningitidis Group Structure of repeating unit Reference A →6)α-D-ManNAc(1-PO4→ (8) 3 ↑ OAc B →8)α-D-NeuNAc(2→ (5) C →9)α-D-NeuNAc(2→ (5) 7/8 ↑ OAc H →4)α-D-Gal (l→2) glycerol 3-PO(4)→ (6) L →3)α-D-GlcNAc (l→3) β-D-GlcNAc (l→3) α-D-GlcNAc-1-PO(4)→ (7) X →4)α-D-GlcNAc-1 -PO(4)→ (4) Y →6)α-D-Glc (l→4) α-D-NeuNAc (2→ (OAc) (9) W135 →6)α-D-Gal (l→4) α-D-NeuNAc (2→ (9) Z →3)α-D-GalNAc (1→1) glycerol 3-PO(4)→ (10) 29E →7)β-D-KDO (l→3) α-D-GalNAc (l→ (11).

Mendeley readers

The data shown below were compiled from readership statistics for 9 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 11%
Unknown 8 89%

Demographic breakdown

Readers by professional status Count As %
Researcher 2 22%
Student > Bachelor 1 11%
Unspecified 1 11%
Other 1 11%
Student > Master 1 11%
Other 0 0%
Unknown 3 33%
Readers by discipline Count As %
Medicine and Dentistry 2 22%
Biochemistry, Genetics and Molecular Biology 1 11%
Unspecified 1 11%
Chemistry 1 11%
Immunology and Microbiology 1 11%
Other 0 0%
Unknown 3 33%

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 April 2012.
All research outputs
#7,454,427
of 22,789,566 outputs
Outputs from Methods in molecular medicine
#9
of 53 outputs
Outputs of similar age
#12,835
of 38,967 outputs
Outputs of similar age from Methods in molecular medicine
#1
of 1 outputs
Altmetric has tracked 22,789,566 research outputs across all sources so far. This one is in the 44th percentile – i.e., 44% of other outputs scored the same or lower than it.
So far Altmetric has tracked 53 research outputs from this source. They receive a mean Attention Score of 3.2. This one is in the 35th percentile – i.e., 35% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 38,967 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 10th percentile – i.e., 10% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them