Chapter title |
Phenotypic Screening of Small Molecules with Antimalarial Activity for Three Different Parasitic Life Stages
|
---|---|
Chapter number | 3 |
Book title |
Phenotypic Screening
|
Published in |
Methods in molecular biology, January 2018
|
DOI | 10.1007/978-1-4939-7847-2_3 |
Pubmed ID | |
Book ISBNs |
978-1-4939-7846-5, 978-1-4939-7847-2
|
Authors |
Nobutaka Kato, Sandra March, Sangeeta N. Bhatia, Matthias Marti, Kato, Nobutaka, March, Sandra, Bhatia, Sangeeta N., Marti, Matthias |
Abstract |
Malaria remains one of the deadliest infectious diseases globally. Available therapeutic agents are already limited in their efficacy, and drug resistance threatens to diminish further our ability to prevent and treat the disease. Despite a renewed effort to identify compounds with antimalarial activity, the drug discovery and development pipeline lacks target diversity and availability of compounds that target liver- and gametocyte-stage parasites. Phenotypic screens are a powerful and valuable tool for identifying new chemical compounds with antimalarial activity. This chapter highlights recent phenotypic screening methodologies for all three parasitic life stages. |
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