| Chapter title |
Decellularized Whole Heart for Bioartificial Heart.
|
|---|---|
| Chapter number | 14 |
| Book title |
Cellular Cardiomyoplasty
|
| Published in |
Methods in molecular biology, June 2013
|
| DOI | 10.1007/978-1-62703-511-8_14 |
| Pubmed ID | |
| Book ISBNs |
978-1-62703-510-1, 978-1-62703-511-8
|
| Authors |
Aubin H, Kranz A, Hülsmann J, Lichtenberg A, Akhyari P, Hug Aubin, Alexander Kranz, Jörn Hülsmann, Artur Lichtenberg, Payam Akhyari |
| Abstract |
Whole-organ decellularization has opened the gates to the creation of 3D extracellular matrix (ECM) templates that mimic nature's design to a degree that-as for today-is not reproducible with any synthetic materials. Here, we describe a whole-heart decellularization approach through software-controlled automated coronary perfusion with standard decellularization detergents, enabling us to create native ECM-derived 3D templates that preserve the basic anatomy, vascular network, and critical ECM characteristics of the native heart. Such a cardiac ECM platform directly derived from nature itself might help us to better understand and reproduce cardiac biology and may even lay the grounds for the construction of a bioartificial heart in the future. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 2 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Italy | 1 | 3% |
| Brazil | 1 | 3% |
| Unknown | 37 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 12 | 31% |
| Student > Master | 6 | 15% |
| Researcher | 4 | 10% |
| Student > Postgraduate | 3 | 8% |
| Other | 2 | 5% |
| Other | 3 | 8% |
| Unknown | 9 | 23% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 8 | 21% |
| Medicine and Dentistry | 7 | 18% |
| Engineering | 6 | 15% |
| Biochemistry, Genetics and Molecular Biology | 4 | 10% |
| Social Sciences | 1 | 3% |
| Other | 1 | 3% |
| Unknown | 12 | 31% |