Chapter title |
Decellularized Whole Heart for Bioartificial Heart.
|
---|---|
Chapter number | 14 |
Book title |
Cellular Cardiomyoplasty
|
Published in |
Methods in molecular biology, June 2013
|
DOI | 10.1007/978-1-62703-511-8_14 |
Pubmed ID | |
Book ISBNs |
978-1-62703-510-1, 978-1-62703-511-8
|
Authors |
Aubin H, Kranz A, Hülsmann J, Lichtenberg A, Akhyari P, Hug Aubin, Alexander Kranz, Jörn Hülsmann, Artur Lichtenberg, Payam Akhyari |
Abstract |
Whole-organ decellularization has opened the gates to the creation of 3D extracellular matrix (ECM) templates that mimic nature's design to a degree that-as for today-is not reproducible with any synthetic materials. Here, we describe a whole-heart decellularization approach through software-controlled automated coronary perfusion with standard decellularization detergents, enabling us to create native ECM-derived 3D templates that preserve the basic anatomy, vascular network, and critical ECM characteristics of the native heart. Such a cardiac ECM platform directly derived from nature itself might help us to better understand and reproduce cardiac biology and may even lay the grounds for the construction of a bioartificial heart in the future. |
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Mendeley readers
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