Chapter title |
Annexins: Ca 2+ Effectors Determining Membrane Trafficking in the Late Endocytic Compartment
|
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Chapter number | 14 |
Book title |
Membrane Dynamics and Calcium Signaling
|
Published in |
Advances in experimental medicine and biology, January 2017
|
DOI | 10.1007/978-3-319-55858-5_14 |
Pubmed ID | |
Book ISBNs |
978-3-31-955857-8, 978-3-31-955858-5
|
Authors |
Carlos Enrich, Carles Rentero, Elsa Meneses-Salas, Francesc Tebar, Thomas Grewal, Enrich, Carlos, Rentero, Carles, Meneses-Salas, Elsa, Tebar, Francesc, Grewal, Thomas |
Abstract |
Despite the discovery of annexins 40 years ago, we are just beginning to understand some of the functions of these still enigmatic proteins. Defined and characterized by their ability to bind anionic membrane lipids in a Ca2+-dependent manner, each annexin has to be considered a multifunctional protein, with a multitude of cellular locations and diverse activities. Underlying causes for this considerable functional diversity include their capability to associate with multiple cytosolic and membrane proteins. In recent years, the increasingly recognized establishment of membrane contact sites between subcellular compartments opens a new scenario for annexins as instrumental players to link Ca2+ signalling with the integration of membrane trafficking in many facets of cell physiology. In this chapter, we review and discuss current knowledge on the contribution of annexins in the biogenesis and functioning of the late endocytic compartment, affecting endo- and exocytic pathways in a variety of physiological consequences ranging from membrane repair, lysosomal exocytosis, to cell migration. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 31 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 6 | 19% |
Student > Bachelor | 3 | 10% |
Other | 2 | 6% |
Student > Master | 2 | 6% |
Student > Ph. D. Student | 2 | 6% |
Other | 3 | 10% |
Unknown | 13 | 42% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 6 | 19% |
Medicine and Dentistry | 3 | 10% |
Agricultural and Biological Sciences | 3 | 10% |
Chemistry | 2 | 6% |
Neuroscience | 1 | 3% |
Other | 1 | 3% |
Unknown | 15 | 48% |