| Chapter title |
Structure-Function Relationship of the Voltage-Gated Calcium Channel Ca v 1.1 Complex
|
|---|---|
| Chapter number | 2 |
| Book title |
Membrane Dynamics and Calcium Signaling
|
| Published in |
Advances in experimental medicine and biology, January 2017
|
| DOI | 10.1007/978-3-319-55858-5_2 |
| Pubmed ID | |
| Book ISBNs |
978-3-31-955857-8, 978-3-31-955858-5
|
| Authors |
Jianping Wu, Nieng Yan, Zhen Yan, Wu, Jianping, Yan, Nieng, Yan, Zhen |
| Abstract |
Voltage-gated calcium (Cav) channels are miniature membrane transistors that convert membrane electrical signals to intracellular Ca2+ transients that trigger many physiological events. In mammals, there are ten subtypes of Cav channel, among which Cav1.1 is the first Cavα1 to be cloned. Cav1.1 is specified for the excitation-contraction coupling of skeletal muscles, and has been a prototype in the structural investigations of Cav channels. This article summarized the recent advances in the structural elucidation of Cav1.1 and the mechanistic insights derived from the 3.6 Å structure obtained using single-particle, electron cryomicroscopy. The structure of the Cav1.1 complex established the framework for mechanistic understanding of excitation-contraction coupling and provides the template for molecular interpretations of the functions and disease mechanisms of Cav and Nav channels. |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 23 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 4 | 17% |
| Researcher | 3 | 13% |
| Student > Doctoral Student | 1 | 4% |
| Student > Bachelor | 1 | 4% |
| Student > Master | 1 | 4% |
| Other | 3 | 13% |
| Unknown | 10 | 43% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 7 | 30% |
| Neuroscience | 3 | 13% |
| Agricultural and Biological Sciences | 1 | 4% |
| Medicine and Dentistry | 1 | 4% |
| Physics and Astronomy | 1 | 4% |
| Other | 0 | 0% |
| Unknown | 10 | 43% |