Chapter title |
Detection of epigenetic aberrations in the development of hepatocellular carcinoma.
|
---|---|
Chapter number | 37 |
Book title |
Cancer Epigenetics
|
Published in |
Methods in molecular biology, January 2015
|
DOI | 10.1007/978-1-4939-1804-1_37 |
Pubmed ID | |
Book ISBNs |
978-1-4939-1803-4, 978-1-4939-1804-1
|
Authors |
Yujing Zhang, Zhang, Yujing |
Abstract |
Hepatocellular carcinoma (HCC) is the third most common cause of cancer death worldwide. Hepatocarcinogenesis is a complex, multistep process. It is now recognized that HCC is a both genetic and epigenetic disease; genetic and epigenetic components cooperate at all stages of hepatocarcinogenesis. Epigenetic changes involve aberrant DNA methylation, posttranslational histone modifications and aberrant expression of microRNAs all of which can affect the expression of oncogenes, tumor suppressor genes and other tumor-related genes and alter the pathways in cancer development. Several risk factors for HCC, including hepatitis B and C virus infections and exposure to the chemical carcinogen aflatoxin B1 have been found to influence epigenetic changes. Their interactions could play an important role in the initiation and progression of HCC. Discovery and detection of biomarkers for epigenetic changes is a promising area for early diagnosis and risk prediction of HCC. |
X Demographics
Geographical breakdown
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France | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Korea, Republic of | 1 | 4% |
United States | 1 | 4% |
Unknown | 26 | 93% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 7 | 25% |
Student > Ph. D. Student | 3 | 11% |
Student > Postgraduate | 2 | 7% |
Student > Master | 2 | 7% |
Other | 1 | 4% |
Other | 3 | 11% |
Unknown | 10 | 36% |
Readers by discipline | Count | As % |
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Biochemistry, Genetics and Molecular Biology | 5 | 18% |
Agricultural and Biological Sciences | 5 | 18% |
Medicine and Dentistry | 4 | 14% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 7% |
Nursing and Health Professions | 1 | 4% |
Other | 1 | 4% |
Unknown | 10 | 36% |