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Group B Coxsackieviruses

Overview of attention for book
Attention for Chapter 15: CVB infection and mechanisms of viral cardiomyopathy.
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Chapter title
CVB infection and mechanisms of viral cardiomyopathy.
Chapter number 15
Book title
Group B Coxsackieviruses
Published in
Current topics in microbiology and immunology, March 2008
DOI 10.1007/978-3-540-75546-3_15
Pubmed ID
Book ISBNs
978-3-54-075545-6, 978-3-54-075546-3
Authors

Knowlton KU, K. U. Knowlton, Knowlton, K. U.

Abstract

Coxsackievirus infection has been demonstrated to be a cause of acute and fulminant viral myocarditis and has been associated with dilated cardiomyopathy. While considerable attention has focused on the role of the cellular and humoral, antigen-specific immune system in viral myocarditis, the interaction between the virus and the infected host myocyte is also important. Coxsackievirus has a relative tropism for the heart that is in part mediated by relatively high levels of the coxsackievirus and adenovirus receptor (CAR) on the cardiac myocyte. Once within the myocyte, coxsackievirus produces proteases, such as protease 2A, that have an important role in viral replication, but can also affect host cell proteins such as dystrophin. Cleavage of dystrophin may have a role in release of the virus from the myocyte since viral infection is increased in the absence of dystrophin. In addition to the direct effect of viral proteins on cardiac myocytes, there is now evidence that the cardiac myocyte has a potent innate immune defense against coxsackieviral infection. Suppressors of cytokine signaling (SOCS) can inhibit an interferon-independent mechanism within the cardiac myocyte. In summary, the interaction between coxsackievirus and the infected myocyte has a significant role in the pathogenesis of viral myocarditis and the susceptibility to viral infection.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 26 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 26 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 7 27%
Student > Ph. D. Student 4 15%
Student > Bachelor 3 12%
Student > Doctoral Student 2 8%
Unspecified 1 4%
Other 3 12%
Unknown 6 23%
Readers by discipline Count As %
Medicine and Dentistry 10 38%
Biochemistry, Genetics and Molecular Biology 5 19%
Veterinary Science and Veterinary Medicine 1 4%
Unspecified 1 4%
Pharmacology, Toxicology and Pharmaceutical Science 1 4%
Other 2 8%
Unknown 6 23%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 March 2013.
All research outputs
#7,454,951
of 22,790,780 outputs
Outputs from Current topics in microbiology and immunology
#201
of 672 outputs
Outputs of similar age
#28,488
of 81,280 outputs
Outputs of similar age from Current topics in microbiology and immunology
#1
of 2 outputs
Altmetric has tracked 22,790,780 research outputs across all sources so far. This one is in the 44th percentile – i.e., 44% of other outputs scored the same or lower than it.
So far Altmetric has tracked 672 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.9. This one has gotten more attention than average, scoring higher than 50% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 81,280 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 18th percentile – i.e., 18% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 2 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them