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Purine and Pyrimidine Metabolism in Man VIII

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Table of Contents

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    Book Overview
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    Chapter 1 Diagnosis and Treatment of Inborn Errors of Purine and Pyrimidine Metabolism: An Overview
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    Chapter 2 Determination of Dihydropyrimidine Dehydrogenase (DPD) in Fibroblasts of a DPD Deficient Pediatric Patient and Family Members using a Polyclonal Antibody to Human DPD
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    Chapter 3 The Effect of Partial Hepatectomy on Blood Purine Levels in Rats and Patients
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    Chapter 4 Abnormal Purine and Pyrimidine Metabolism in Inherited Superactivity of PRPP Synthetase
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    Chapter 5 Accelerated purine base salvage--a possible cause of elevated nucleotide pool in the erythrocytes of patients with uraemia.
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    Chapter 6 Quantitation of TK1 mRNA in Patients with Chronic Lymphatic Leukemia
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    Chapter 7 Effect of Hypouricemic Agents on Serum Carbohydrate-Deficient Transferrin in Gouty Patients
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    Chapter 8 Renal Hemodynamic in Familial Nephropathy Associated with Hyperuricemia (FNAH)
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    Chapter 9 Renal Urate Hypoexcretion in Polynesian Women is not as Severe as in United Kingdom (UK) Women with Familial Juvenile Hyperuricaemic Nephropathy (FJHN)
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    Chapter 10 Renal Clearances of Purine Bases and Oxypurinol During Glucose Infusion
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    Chapter 11 In Vitro and In Vivo Study on the Conversion of Allopurinol and Pyrazinamide
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    Chapter 12 Free Oxypurines in Plasma and Urine of Gout Patients Before and After a Purine-Free Diet
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    Chapter 13 Analysis of the Genotypes for Aldehyde Dehydrogenase 2 in Japanese Patients with Primary Gout
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    Chapter 14 Hypouricemia and an Increased Clearance of Uric Acid are Observed in Liver Diseases?
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    Chapter 15 The Influence of Allopurinol on Renal Deterioration in Familial Nepropathy Associated with Hyperuricemia (FNAH)
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    Chapter 16 Ultrasound Imaging and Colour Doppler Studies in Familial Nephropathy Associated with Hyperuricemia (FNAH)
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    Chapter 17 Purine Metabolism in Female Patients with Primary Gout
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    Chapter 18 Familial Juvenile Hyperuricaemic Nephropathy in Adolescents
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    Chapter 19 Correlation of Serum Uric Acid, Cholesterol and Triglyceride Levels
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    Chapter 20 Serum Concentration of Lp(a) in Patients with Primary Gout
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    Chapter 21 Study on Lipoprotein Lipase and Hepatic Triglyceride Lipase Activities in Patients with Gout
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    Chapter 22 Benzbromarone and Fenofibrate are Lipid Lowering and Uricosuric: A Possible Key to Metabolic Syndrome?
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    Chapter 23 The Normal Range of Serum Urate Levels and of Fractional Urate Excretion
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    Chapter 24 Therapy Related Disturbances in Nucleotides in Cancer Cells
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    Chapter 25 Comparison of 5-Fluoro-2’-Deoxyuridine and 5-Fluorouracil in the Treatment of Murine Colon Cancer; Effects on Thymidylate Synthase
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    Chapter 26 Intracellular Pharmacology and Biochemistry of Methotrexate and 6-Mercaptopurine in Childhood Acute Lymphoblastic Leukemia
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    Chapter 27 Modulation of arabinosylcytosine metabolism during leukemia therapy.
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    Chapter 28 A new mechanism of toxicity of 2-chlorodeoxyadenosine (2CdA).
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    Chapter 29 The influence of 2-chlorodeoxyadenosine (2-CdA) alone and in combination with cyclophosphamide or methotrexate on normal and leukemic hematopoiesis.
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    Chapter 30 Utilization of Purine and Pyrimidine in Human Gastric Cancer Cells (Kato III): Effect of a Nucleotide and Nucleosides Mixture (OG-VI) Solution on Proliferation with Coadministration of 5-Fluorouracil
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    Chapter 31 Inhibition of the Proliferation of Human Cancer Cells In-Vitro by Substrate-Analogous Inhibitors of dUTPase
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    Chapter 32 Synergistic Interaction between Cisplatin and Gemcitabine in Ovarian and Colon Cancer Cell Lines
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    Chapter 33 Antimetabolites Reduce the Activities of Enzymes with Short Half-Lives in Addition to Inhibiting their Specific Targets
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    Chapter 34 Inhibition of Murine Amido Phosphoribosyltransferase by Folate Derivatives
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    Chapter 35 Inosine 5’-Monophosphate Dehydrogenase as a Chemotherapeutic Target
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    Chapter 36 Pharmacokinetics/Pharmacodynamics of CI-1000, a Purine Nucleoside Phosphorylase (PNP) Inhibitor, in Rats and Monkeys
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    Chapter 37 Blockade of Nucleoside Degradation in Monkey Whole Blood in Vitro by CI-1000, a Purine Nucleoside Phosphorylase (PNP) Inhibitor
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    Chapter 38 Changes in Monkey Plasma Purines Induced by Repeated Doses of CI-1000, a Novel Inhibitor of Purine Nucleoside Phosphorylase
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    Chapter 39 Inhibitors of Thymidylate Synthase and Glycinamide Ribonucleotide Transformylase
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    Chapter 40 The Antitumour Activity of ZD9331, a Non-Polyglutamatable Quinazoline Thymidylate Synthase Inhibitor
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    Chapter 41 Cross-resistance to thymidylate synthase inhibitors in P-glycoprotein and non-P-glycoprotein cell lines.
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    Chapter 42 Nucleotide Metabolism: Mode of Action of Thiopurines in Leukemia
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    Chapter 43 Mitochondrial Versus Cytosolic Activities of Deoxyribonucleoside Salvage Enzymes
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    Chapter 44 Does Low-Dose Allopurinol, with Azathioprine, Cyclosporin and Prednisolone, Improve Renal Transplant Immunosuppression?
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    Chapter 45 Purine nucleotide interconversion enzymes in childhood leukemia: relation with cell cycle and clinical outcome.
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    Chapter 46 Behavior of Enzymes Involved in Purine Nucleotide Metabolism in Tumors
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    Chapter 47 Purine and pyrimidine metabolisms in human gliomas, melanomas and colon carcinomas xenografts, relation to their cytogenetic profile.
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    Chapter 48 Ecto-5’-Nucleotidase Activity in Lymphocytes from Healthy and Leukemia Patients
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    Chapter 49 Endo-5’-Nucleotidase Activity in Lymphocytes from Healthy Subjects and Leukemia Patients
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    Chapter 50 Purine nucleotide content in the leukocytes of leukemia patients.
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    Chapter 51 AMP-Deaminase from Human Uterine Muscle Neoplasm (Leiomyoma)
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    Chapter 52 Regulation of Gene Expression of Adenosine Deaminase, Purine Nucleoside Phosphorylase and Terminal Deoxynucleotidyl Transferase by Dexamethasone and cAMP in Human Leukemic Cells
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    Chapter 53 Altered substrate and inhibitor specificity of purified human adult thymidine kinases (TK2) from leukemic cells.
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    Chapter 54 Elevated Ratio between Deoxycytidine Kinase and Thymidine Kinase 2 in CLL Lymphocytes Compared to Control Cells
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    Chapter 55 The Roles of Uridine-Cytidine Kinase and CTP Synthetase in the Synthesis of CTP in Malignant Human T-Lymphocytic Cells
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    Chapter 56 Metabolism of UDP-N-Acetyl-Hexoses and UDP-Hexoses in Normal Human T-Lymphocytes and MOLT-3 T-Leukemia Cells
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    Chapter 57 Pattern of Methylated Purine Bases in Urine of Cancer Patients. Analysis by Mass Spectrometry
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    Chapter 58 Cytotoxicity of Deoxycoformycin on Human Colon Carcinoma Cell Lines
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    Chapter 59 Imbalance between the Pyrimidine Ribonucleotide Pools in Rat Rhabdomyosarcoma R1 Cells
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    Chapter 60 Compartmentation of Ribonucleotides in PC-12 Cells: Free and Protein Bound Ribonucleotides
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    Chapter 61 The effect of ischemic preconditioning on nucleotide metabolism and function of rat heart after prolonged cold storage
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    Chapter 62 Does Adenosine Deaminase Inhibition Protect Ischemic Myocardium?
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    Chapter 63 Is Hypoxanthine a Useful Marker of Perinatal Hypoxia?
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    Chapter 64 Endothelial Cells’ Responses to Hypoxia and Reperfusion
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    Chapter 65 Inhibition of Lipid Peroxidation by Purines and Analogues of Purine
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    Chapter 66 A Study of Anoxia in Rat Hepatocytes
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    Chapter 67 Adenine Nucleotide Levels and Lipid Peroxidation at Hypoxia and Reoxygenation in Different Cell Types
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    Chapter 68 Purine and pyrimidine catabolite production in the postischemic rat heart--effect of adenosine supply during reperfusion.
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    Chapter 69 The AMP — Adenosine Cycle is Active During Normoxia and Impaired in ATP Depletion in Isolated Rabbit Cardiomyocytes
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    Chapter 70 Search for the Mechanisms of High Incidence of APRT Deficiency Among Japanese
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    Chapter 71 Genetic and Clinical Heterogeneity in Hypoxanthine Phosphoribosyltransferase Deficiencies
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    Chapter 72 Molecular Mechanisms of the Second Female Lesch-Nyhan Patient
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    Chapter 73 Clinical Symptoms of Patients with Partial HPRT Deficiency
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    Chapter 74 Normal Hypoxanthine and Ammonia Release from Working Muscle in Partial HPRT Deficiency
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    Chapter 75 Altered Pyridine Metabolism in the Erythrocytes of a Mentally Retarded Infant with Partial HPRT Deficiency
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    Chapter 76 Treatment of Lesch-Nyhan Syndrome with AICAR
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    Chapter 77 Plasma and Urinary Oxypurines in Lesch-Nyhan Patient after Allopurinol Treatment
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    Chapter 78 Adenylosuccinate Lyase Deficiency: An Update
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    Chapter 79 Adenylosuccinate Lyase Deficiency in a Czech Girl and Two Siblings
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    Chapter 80 Anomalous Response to Intravenous Fructose Tolerance Test in a Case of Deficit of Adenylosuccinate Lyase
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    Chapter 81 Effect of Allopurinol on the Xanthinuria in a Patient with Molybdenum Cofactor Deficiency
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    Chapter 82 Differential diagnosis of main rheumatic diseases in man.
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    Chapter 83 Dihydropyrimidinuria: The First Case in Japan
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    Chapter 84 Normal Uric Acid Concentrations in a Purine Nucleoside Phosphorylase (PNP) Deficient Child Presenting with Severe Chicken Pox, Possible Immunodeficiency and Developmental Delay
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    Chapter 85 Biochemical and Immunological Status Following Gene Therapy and PEG-ADA Therapy for Adenosine Deaminase (ADA) Deficiency
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    Chapter 86 Genetic Manipulation of Hematopoietic Stem Cells in Adenosine Deaminase Deficiency
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    Chapter 87 A1 Adenosine Receptors in Human Neutrophils: Electron Microscope Localization Using a Colloidal Cha-Gold-Albumin Probe
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    Chapter 88 A 2 Adenosine Receptors in Neutrophils from Healthy Volunteers and Patients with Rheumatoid Arthritis
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    Chapter 89 The Antiinflammatory Effects of Methotrexate are Mediated by Adenosine
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    Chapter 90 Endogenous Adenosine Formation can Regulate Human Neutrophil Function
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    Chapter 91 Acadesine: Preclinical Overview
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    Chapter 92 Regulation of Endogenous Adenosine Levels in the CNS: Potential for Therapy in Stroke, Epilepsy and Pain
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    Chapter 93 Enzymes of adenosine metabolism in the heart, cardiomyocytes and endothelium
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    Chapter 94 Adenosine uptake and metabolism in human endothelial cells.
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    Chapter 95 SAH-hydrolase activity in haemolysate and intact erythrocytes; the effect of adenosine analogues
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    Chapter 96 Chemotherapeutic Options in HIV Infection
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    Chapter 97 Changes of Purine Nucleotide Content in Lymphocytes from Patients Infected with Human Immunodeficiency Virus
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    Chapter 98 Anti-Retroviral and Pharmacological Properties of 9-(2-Phosphonylmethoxyethyl)Adenine (PMEA)
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    Chapter 99 Properties of Mitochondrial DNA Metabolising Enzymes; Implications for Chemotherapy
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    Chapter 100 Adenosine deaminase (ADA) deficiency as the unexpected cause of CD4+ T-lymphocytopenia in two HIV-negative adult female siblings.
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    Chapter 101 Serum guanase activity in hepatitis C virus infection.
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    Chapter 102 Ganciclovir Nucleotide Analysis in Human Myocardial Tissue. Usefulness in the Diagnosis of Cytomegalovirus Myocarditis
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    Chapter 103 Toxicity of Adenosine Analogues against Human Malaria ( Plasmodium falciparum )
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    Chapter 104 Altered Purine Nucleoside Transport as a Target for Malaria Chemotherapy
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    Chapter 105 Quantitative Determination of Trypanosoma cruzi Growth inside Host Cells in Vitro and Effect of Allopurinol
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    Chapter 106 Polyamine Content of Acanthamoeba polyphaga at Different Stages of Development and the Effect of Pentamidine
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    Chapter 107 Specific Enzyme Synthesizing Adenosine from Adenine and Ribose-1-Phosphate in Invertebrates
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    Chapter 108 Molecular Characterization of a Carbamoyl-Phosphate Synthetase II (CPS II) Gene from Trypanosoma cruzi
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    Chapter 109 Development of a Mouse Model for the Study of Human Purine Metabolism
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    Chapter 110 Effect of galactosamine on adenine and uracil nucleotide levels in isolated hepatocytes of young and old rats.
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    Chapter 111 Influence of Purines on Endothelial High Energy Phosphates
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    Chapter 112 Ribose 1-P-Dependent ADP and ATP Formation in Rat Liver
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    Chapter 113 Myocardial 5’Deoxy-5’Methylthioadenosine Phosphorylase
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    Chapter 114 A Nucleoside Mixture and its Sparing Effect on de novo Purine Nucleotide Synthesis
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    Chapter 115 de novo Pyrimidine Nucleotide Biosynthesis in Synchronized Chinese Hamster Ovary Cells
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    Chapter 116 The Catalytic Mechanism of Hamster Dihydroorotase
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    Chapter 117 Stimulation by 6-Azauridine of de novo Pyrimidine Biosynthesis in BHK 165-23 Cells
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    Chapter 118 Observed Resistance to Pyrimidine Analogs and Sensitivity to Uracil in Drosophila is attributed to Deregulation of Pyrimidine Metabolism
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    Chapter 119 Expression of de novo Pyrimidine Biosynthesis Genes during Spermatogenesis in Drosophila melanogaster
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    Chapter 120 Regulation of Calf Thymus Cytosolic 5’-Nucleotidase/Nucleoside Phosphotransferase
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    Chapter 121 Diverse Genetic Regulatory Elements are Required to Direct the Proper Tissue-Specific and Developmental Expression of the Murine Adenosine Deaminase Gene
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    Chapter 122 The muscle and nonmuscle isozymes of adenylosuccinate synthetase are encoded by separate genes with differential patterns of expression.
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    Chapter 123 Expressing Enzymatic Domains of Hamster CAD in CAD-Deficient Chinese Hamster Ovary Cells
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    Chapter 124 Homology and mutagenesis studies of hamster dihydroorotase.
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    Chapter 125 Evolution of the GATase, CPSase, DHOase-LIKE, ATCase Multifunctional Protein in Eukaryotes: Genetic and Molecular Approaches with Yeasts S. cerevisiae and S. pombe
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    Chapter 126 Nucleoside Diphosphate Kinase: an Old Enzyme with New Functions?
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    Chapter 127 Production of Adenosine and Nucleoside Analogues by an Exchange Reaction Catalyzed by Adenosine Kinase
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    Chapter 128 Different Substrate Specificity of Two Isozymes of Cytosolic 5’-Nucleotidase from Rabbit Heart
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    Chapter 129 Human Placental Cytosolic Purine 5’-Nucleotidase is Effectively Reactive with an Anti-Chicken Liver Enzyme Antibody
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    Chapter 130 Characterization of the Adenine Phosphoribosyltransferase from Saccharomyces cerevisiae
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    Chapter 131 Differential Substrate Properties of Mammalian Ribonucleotide Reductase
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    Chapter 132 Altered Kinetic Properties of Recombinant Human Cytosolic Thymidine Kinase (TK1) as Compared with the Native Form
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    Chapter 133 The Promoter of the Cho APRT Gene Contains Three Regulatory Regions
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    Chapter 134 The Mouse APRT Gene as a Model for Studying Epigenetic Gene Inactivation
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    Chapter 135 Analysis of in Vivo Somatic Mutations at the APRT Locus
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    Chapter 136 Identification of Polymorphic Markers Flanking the Human APRT Gene
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    Chapter 137 Germline and somatic mutation at the APRT locus of mice and man.
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    Chapter 138 Isolation and Characterization of Mutations in the Mouse APRT Gene that Encode Functional Enzymes with Resistance to Toxic Adenine Analogs
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    Chapter 139 Analysis of APRT Mutations by Reverse-Transcription PCR
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    Chapter 140 Molecular Characterization of a Novel Mutation in APRT Heterozygotes
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    Chapter 141 Direct Evidence for a Hot Spot of Germline Mutation at HPRT Locus
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    Chapter 142 Regulation of low Km (ecto-) 5'-nucleotidase gene expression in leukemic cells.
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    Chapter 143 Ecto-5’-Nucleotidase (CD73): Genomic Cloning and Characterization of Regions Upstream of the Translation Start Site
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    Chapter 144 Molecular Cloning and Sequence Analyses of Rat Liver Dihydroorotate Dehydrogenase
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    Chapter 145 Mutagenesis Studies of Conserved Residues in Mammalian Dihydroorotase
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    Chapter 146 Gene Mutations for Human Erythrocyte AMP Deaminase Deficiency
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    Chapter 147 Point mutations in PRPS1, the gene encoding the PRPP synthetase (PRS) 1 isoform, underlie X-linked PRS superactivity associated with purine nucleotide inhibitor-resistance.
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    Chapter 148 2’, 3’-Dideoxycytidine Phosphorylation by Recombinant Mouse and Human Deoxycytidine Kinase
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    Chapter 149 Feedback of S. cerevisiae CPSase-ATcase: Selection, Cloning and Sequencing of Mutant Alleles
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    Chapter 150 Gene Structure and Regulation of the Expression of the R1 and R2 Subunits of Mouse Ribonucleotide Reductase
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    Chapter 151 Molecular Characterization of IMP Dehydrogenase in Acquired Resistance to Mycophenolic Acid
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    Chapter 152 Function of the Polypeptide Chain Segment Connecting the Dihydroorotase and Aspartate Transcarbamylase Domains in the Mammalian Multifunctional CAD
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    Chapter 153 Mapping a Gene that Determines Erythrocytic Guanosine-5’-Triphosphate Concentration (Gtpc) on Mouse Chromosome 9
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    Chapter 154 Regulation of Mammalian Serine Hydroxymethyltransferase
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    Chapter 155 Regulation and Role of Inosine-5’-Monophosphate Dehydrogenase in Cell Replication, Malignant Transformation, and Differentiation
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    Chapter 156 Reciprocal alterations of enzymic phenotype of purine and pyrimidine metabolism in induced differentiation of leukemia cells.
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    Chapter 157 Extracellular Concentrations of Oxypurines in Xanthine Oxidase-Deficient Hepatoma-Derived Cell Line HuH-7
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    Chapter 158 Induction of cell differentiation by IMPDH antisense oligomer in HL-60 and K562 human leukemia cell lines.
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    Chapter 159 Inhibition of CTP synthetase induces differentiation of HL-60 cells and down-regulation of the c-myc oncogene.
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    Chapter 160 Adenosine transport and metabolism in cardiomyocytes of hyperthyroid rat.
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    Chapter 161 Nucleoside Transport and Metabolism in Lymphocytes, Polymorphonuclear Cells and Cerebral Synaptosomes
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    Chapter 162 Inhibition of Nucleoside Transport by Reactive Oxygen Species in Bovine Heart Microvascular Endothelial Cells
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    Chapter 163 Novel Nucleoside Transport Inhibitors of Natural Origin
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    Chapter 164 Modification of Tumor Necrosis Factor (TNF) Production and Survival Rate by a Nucleoside Mixture in Lipopolysaccharide-Injected Rats
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    Chapter 165 The Effect of Dietary Nucleic Acid Deficiency and the Administration of a Nucleotide and Nucleosides Mixture Solution on Endotoxin Shock in Rats
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    Chapter 166 Radioimmunoassay of Folic Acid and its Correlation with Age
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    Chapter 167 Uric Acid and Allantoin in Rat Liver after Oxonic Acid and 14 C-Formate
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    Chapter 168 The Measurement of Deoxynucleotide (dNTP) Pools by Radioimmunoassay (RIA)
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    Chapter 169 Rapid Simultaneous Measurement of Nucleotides, Nucleosides and Bases in Tissues by Capillary Electrophoresis
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    Chapter 170 Application of Capillary Zone Electrophoresis for Rapid Screening of Enzymatic Defects in Purine Metabolism
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    Chapter 171 A Reverse-Phase HPLC Method for Cyclic Nucleotide Phosphodiesterases Activity and Classification
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    Chapter 172 Determination of the Activity of Recombinant Human Phosphoribosylpyrophosphate Synthetase Isoform 1 by a Non-Isotopic, One-Step Method
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Title
Purine and Pyrimidine Metabolism in Man VIII
Published by
Springer US, November 2013
DOI 10.1007/978-1-4615-2584-4
ISBNs
978-1-4613-6105-3, 978-1-4615-2584-4
Editors

Sahota, Amrik, Taylor, Milton W.

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Country Count As %
Unknown 2 100%

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Readers by professional status Count As %
Student > Ph. D. Student 2 100%
Readers by discipline Count As %
Pharmacology, Toxicology and Pharmaceutical Science 1 50%
Agricultural and Biological Sciences 1 50%