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Biological Basis of Alcohol-Induced Cancer

Overview of attention for book
Cover of 'Biological Basis of Alcohol-Induced Cancer'

Table of Contents

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    Book Overview
  2. Altmetric Badge
    Chapter 1 Introduction
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    Chapter 2 Alcohol and Breast Cancer: Reconciling Epidemiological and Molecular Data.
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    Chapter 3 Genetic-epidemiological evidence for the role of acetaldehyde in cancers related to alcohol drinking.
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    Chapter 4 Alcohol and Cancer: An Overview with Special Emphasis on the Role of Acetaldehyde and Cytochrome P450 2E1
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    Chapter 5 Implications of Acetaldehyde-Derived DNA Adducts for Understanding Alcohol-Related Carcinogenesis.
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    Chapter 6 The Role of Iron in Alcohol-Mediated Hepatocarcinogenesis
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    Chapter 7 Alcoholic Cirrhosis and Hepatocellular Carcinoma
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    Chapter 8 TLR4-Dependent Tumor-Initiating Stem Cell-Like Cells (TICs) in Alcohol-Associated Hepatocellular Carcinogenesis.
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    Chapter 9 Synergistic Toxic Interactions Between CYP2E1, LPS/TNFα, and JNK/p38 MAP Kinase and Their Implications in Alcohol-Induced Liver Injury.
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    Chapter 10 Understanding the Tumor Suppressor PTEN in Chronic Alcoholism and Hepatocellular Carcinoma.
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    Chapter 11 Alcohol Consumption, Wnt/β-Catenin Signaling, and Hepatocarcinogenesis
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    Chapter 12 Alcohol and HCV: Implications for Liver Cancer.
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    Chapter 13 Application of mass spectrometry-based metabolomics in identification of early noninvasive biomarkers of alcohol-induced liver disease using mouse model.
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    Chapter 14 Alcohol metabolism by oral streptococci and interaction with human papillomavirus leads to malignant transformation of oral keratinocytes.
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    Chapter 15 Genetic Polymorphisms of Alcohol Dehydrogense-1B and Aldehyde Dehydrogenase-2, Alcohol Flushing, Mean Corpuscular Volume, and Aerodigestive Tract Neoplasia in Japanese Drinkers
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    Chapter 16 Acetaldehyde and Retinaldehyde-Metabolizing Enzymes in Colon and Pancreatic Cancers
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    Chapter 17 Alcohol, Carcinoembryonic Antigen Processing and Colorectal Liver Metastases.
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    Chapter 18 Alcohol Consumption and Antitumor Immunity: Dynamic Changes from Activation to Accelerated Deterioration of the Immune System.
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    Chapter 19 A Perspective on Chemoprevention by Resveratrol in Head and Neck Squamous Cell Carcinoma
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    Chapter 20 The Effects of Alcohol and Aldehyde Dehydrogenases on Disorders of Hematopoiesis
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    Chapter 21 The Effect of Alcohol on Sirt1 Expression and Function in Animal and Human Models of Hepatocellular Carcinoma (HCC).
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    Chapter 22 Transgenic mouse models for alcohol metabolism, toxicity, and cancer.
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    Chapter 23 Fetal Alcohol Exposure Increases Susceptibility to Carcinogenesis and Promotes Tumor Progression in Prostate Gland
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    Chapter 24 Fetal alcohol exposure and mammary tumorigenesis in offspring: role of the estrogen and insulin-like growth factor systems.
Attention for Chapter 19: A Perspective on Chemoprevention by Resveratrol in Head and Neck Squamous Cell Carcinoma
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#31 of 4,715)
  • High Attention Score compared to outputs of the same age (98th percentile)
  • High Attention Score compared to outputs of the same age and source (99th percentile)

Mentioned by

news
9 news outlets
blogs
3 blogs
twitter
5 tweeters

Citations

dimensions_citation
12 Dimensions

Readers on

mendeley
26 Mendeley
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Chapter title
A Perspective on Chemoprevention by Resveratrol in Head and Neck Squamous Cell Carcinoma
Chapter number 19
Book title
Biological Basis of Alcohol-Induced Cancer
Published in
Advances in experimental medicine and biology, November 2015
DOI 10.1007/978-3-319-09614-8_19
Pubmed ID
Book ISBNs
978-3-31-909613-1, 978-3-31-909614-8
Authors

Sangeeta Shrotriya, Rajesh Agarwal, Robert A. Sclafani, Shrotriya, Sangeeta, Agarwal, Rajesh, Sclafani, Robert A.

Abstract

Head and neck squamous cell carcinoma (HNSCC) accounts for around 6 % of all cancers in the USA. Few of the greatest obstacles in HNSCC include development of secondary primary tumor, resistance and toxicity associated with the conventional treatments, together decreasing the overall 5-year survival rate in HNSCC patients to ≤50 %. Radiation and chemotherapy are the conventional treatment options available for HNSCC patients at both early and late stage of this cancer type malignancy. Unfortunately, patients response poorly to these therapies leading to relapsed cases, which further, emphasizes the need of additional strategies for the prevention/intervention of both primary and the secondary primary tumors post-HNSCC therapy. In recent years, growing interest has focused on the use of natural products or their analogs to reduce the incidence and mortality of cancer, leading to encouraging results. Resveratrol, a component from grape skin, is one of the well-studied agents with a potential role in cancer chemoprevention and other health benefits. As an anticancer agent, resveratrol suppresses metabolic activation of pro-carcinogens to carcinogens by modulating the metabolic enzymes responsible for their activation, and induces phase II enzymes, thus, further detoxifying the effect of pro-carcinogens. Resveratrol also inhibits cell growth and induces cell death in cancer cells by targeting cell survival and cell death regulatory pathways. Growing evidence also suggest that resveratrol directly binds to DNA and RNA, activates antioxidant enzymes, prevents inflammation, and stimulates DNA damage checkpoint kinases affecting genomic integrity more specifically in malignant cells.

Twitter Demographics

The data shown below were collected from the profiles of 5 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 26 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Australia 1 4%
Unknown 25 96%

Demographic breakdown

Readers by professional status Count As %
Researcher 5 19%
Student > Master 5 19%
Student > Bachelor 5 19%
Other 4 15%
Student > Ph. D. Student 3 12%
Other 1 4%
Unknown 3 12%
Readers by discipline Count As %
Medicine and Dentistry 12 46%
Agricultural and Biological Sciences 5 19%
Environmental Science 1 4%
Pharmacology, Toxicology and Pharmaceutical Science 1 4%
Mathematics 1 4%
Other 3 12%
Unknown 3 12%

Attention Score in Context

This research output has an Altmetric Attention Score of 97. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 March 2020.
All research outputs
#330,191
of 21,387,197 outputs
Outputs from Advances in experimental medicine and biology
#31
of 4,715 outputs
Outputs of similar age
#4,637
of 346,036 outputs
Outputs of similar age from Advances in experimental medicine and biology
#3
of 310 outputs
Altmetric has tracked 21,387,197 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,715 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.7. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 346,036 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 98% of its contemporaries.
We're also able to compare this research output to 310 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 99% of its contemporaries.