↓ Skip to main content

Biological Basis of Alcohol-Induced Cancer

Overview of attention for book
Cover of 'Biological Basis of Alcohol-Induced Cancer'

Table of Contents

  1. Altmetric Badge
    Book Overview
  2. Altmetric Badge
    Chapter 1 Introduction
  3. Altmetric Badge
    Chapter 2 Alcohol and Breast Cancer: Reconciling Epidemiological and Molecular Data.
  4. Altmetric Badge
    Chapter 3 Genetic-epidemiological evidence for the role of acetaldehyde in cancers related to alcohol drinking.
  5. Altmetric Badge
    Chapter 4 Alcohol and Cancer: An Overview with Special Emphasis on the Role of Acetaldehyde and Cytochrome P450 2E1
  6. Altmetric Badge
    Chapter 5 Implications of Acetaldehyde-Derived DNA Adducts for Understanding Alcohol-Related Carcinogenesis.
  7. Altmetric Badge
    Chapter 6 The Role of Iron in Alcohol-Mediated Hepatocarcinogenesis
  8. Altmetric Badge
    Chapter 7 Alcoholic Cirrhosis and Hepatocellular Carcinoma
  9. Altmetric Badge
    Chapter 8 TLR4-Dependent Tumor-Initiating Stem Cell-Like Cells (TICs) in Alcohol-Associated Hepatocellular Carcinogenesis.
  10. Altmetric Badge
    Chapter 9 Synergistic Toxic Interactions Between CYP2E1, LPS/TNFα, and JNK/p38 MAP Kinase and Their Implications in Alcohol-Induced Liver Injury.
  11. Altmetric Badge
    Chapter 10 Understanding the Tumor Suppressor PTEN in Chronic Alcoholism and Hepatocellular Carcinoma.
  12. Altmetric Badge
    Chapter 11 Alcohol Consumption, Wnt/β-Catenin Signaling, and Hepatocarcinogenesis
  13. Altmetric Badge
    Chapter 12 Alcohol and HCV: Implications for Liver Cancer.
  14. Altmetric Badge
    Chapter 13 Application of mass spectrometry-based metabolomics in identification of early noninvasive biomarkers of alcohol-induced liver disease using mouse model.
  15. Altmetric Badge
    Chapter 14 Alcohol metabolism by oral streptococci and interaction with human papillomavirus leads to malignant transformation of oral keratinocytes.
  16. Altmetric Badge
    Chapter 15 Genetic Polymorphisms of Alcohol Dehydrogense-1B and Aldehyde Dehydrogenase-2, Alcohol Flushing, Mean Corpuscular Volume, and Aerodigestive Tract Neoplasia in Japanese Drinkers
  17. Altmetric Badge
    Chapter 16 Acetaldehyde and Retinaldehyde-Metabolizing Enzymes in Colon and Pancreatic Cancers
  18. Altmetric Badge
    Chapter 17 Alcohol, Carcinoembryonic Antigen Processing and Colorectal Liver Metastases.
  19. Altmetric Badge
    Chapter 18 Alcohol Consumption and Antitumor Immunity: Dynamic Changes from Activation to Accelerated Deterioration of the Immune System.
  20. Altmetric Badge
    Chapter 19 A Perspective on Chemoprevention by Resveratrol in Head and Neck Squamous Cell Carcinoma
  21. Altmetric Badge
    Chapter 20 The Effects of Alcohol and Aldehyde Dehydrogenases on Disorders of Hematopoiesis
  22. Altmetric Badge
    Chapter 21 The Effect of Alcohol on Sirt1 Expression and Function in Animal and Human Models of Hepatocellular Carcinoma (HCC).
  23. Altmetric Badge
    Chapter 22 Transgenic mouse models for alcohol metabolism, toxicity, and cancer.
  24. Altmetric Badge
    Chapter 23 Fetal Alcohol Exposure Increases Susceptibility to Carcinogenesis and Promotes Tumor Progression in Prostate Gland
  25. Altmetric Badge
    Chapter 24 Fetal alcohol exposure and mammary tumorigenesis in offspring: role of the estrogen and insulin-like growth factor systems.
Attention for Chapter 10: Understanding the Tumor Suppressor PTEN in Chronic Alcoholism and Hepatocellular Carcinoma.
Altmetric Badge

Citations

dimensions_citation
14 Dimensions

Readers on

mendeley
12 Mendeley
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Chapter title
Understanding the Tumor Suppressor PTEN in Chronic Alcoholism and Hepatocellular Carcinoma.
Chapter number 10
Book title
Biological Basis of Alcohol-Induced Cancer
Published in
Advances in experimental medicine and biology, January 2015
DOI 10.1007/978-3-319-09614-8_10
Pubmed ID
Book ISBNs
978-3-31-909613-1, 978-3-31-909614-8
Authors

Colin T Shearn, Dennis R Petersen, Colin T. Shearn, Dennis R. Petersen, Shearn, Colin T., Petersen, Dennis R.

Abstract

The tumor suppressor phosphatase and tensin homolog deleted on chromosome 10 (PTEN) is a phosphatidylinositol (PtdIns) phosphatase that regulates Akt activation via PtdIns 3 kinase. Changes in PTEN expression and/or activity have been identified in a variety of chronic hepatocellular disorders including obesity, NAFLD, NASH, and alcoholism. In cancer biology, PTEN is frequently mutated or deleted in a wide variety of tumors. Mutations, decreased promoter activity, and decreased expression in PTEN are frequently identified in patients with hepatocellular carcinoma. While the majority of research on PTEN concerns obesity and NASH, PTEN clearly has a role in hepatic insulin sensitivity and in the development of steatosis during chronic alcoholism. Yet, in chronic alcoholics and HCC, very little is known concerning PTEN mutation/deletion or low PTEN expression. This review is focused on an overview of the current knowledge on molecular mechanisms of dysregulation of PTEN expression/activity in the liver and their relationship to development of ethanol-induced hepatocellular damage and cancer.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 12 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 12 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 5 42%
Researcher 3 25%
Student > Doctoral Student 1 8%
Unspecified 1 8%
Other 1 8%
Other 1 8%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 5 42%
Medicine and Dentistry 2 17%
Agricultural and Biological Sciences 2 17%
Pharmacology, Toxicology and Pharmaceutical Science 1 8%
Unspecified 1 8%
Other 0 0%
Unknown 1 8%