↓ Skip to main content

Biological Basis of Alcohol-Induced Cancer

Overview of attention for book
Cover of 'Biological Basis of Alcohol-Induced Cancer'

Table of Contents

  1. Altmetric Badge
    Book Overview
  2. Altmetric Badge
    Chapter 1 Introduction
  3. Altmetric Badge
    Chapter 2 Alcohol and Breast Cancer: Reconciling Epidemiological and Molecular Data.
  4. Altmetric Badge
    Chapter 3 Genetic-epidemiological evidence for the role of acetaldehyde in cancers related to alcohol drinking.
  5. Altmetric Badge
    Chapter 4 Alcohol and Cancer: An Overview with Special Emphasis on the Role of Acetaldehyde and Cytochrome P450 2E1
  6. Altmetric Badge
    Chapter 5 Implications of Acetaldehyde-Derived DNA Adducts for Understanding Alcohol-Related Carcinogenesis.
  7. Altmetric Badge
    Chapter 6 The Role of Iron in Alcohol-Mediated Hepatocarcinogenesis
  8. Altmetric Badge
    Chapter 7 Alcoholic Cirrhosis and Hepatocellular Carcinoma
  9. Altmetric Badge
    Chapter 8 TLR4-Dependent Tumor-Initiating Stem Cell-Like Cells (TICs) in Alcohol-Associated Hepatocellular Carcinogenesis.
  10. Altmetric Badge
    Chapter 9 Synergistic Toxic Interactions Between CYP2E1, LPS/TNFα, and JNK/p38 MAP Kinase and Their Implications in Alcohol-Induced Liver Injury.
  11. Altmetric Badge
    Chapter 10 Understanding the Tumor Suppressor PTEN in Chronic Alcoholism and Hepatocellular Carcinoma.
  12. Altmetric Badge
    Chapter 11 Alcohol Consumption, Wnt/β-Catenin Signaling, and Hepatocarcinogenesis
  13. Altmetric Badge
    Chapter 12 Alcohol and HCV: Implications for Liver Cancer.
  14. Altmetric Badge
    Chapter 13 Application of mass spectrometry-based metabolomics in identification of early noninvasive biomarkers of alcohol-induced liver disease using mouse model.
  15. Altmetric Badge
    Chapter 14 Alcohol metabolism by oral streptococci and interaction with human papillomavirus leads to malignant transformation of oral keratinocytes.
  16. Altmetric Badge
    Chapter 15 Genetic Polymorphisms of Alcohol Dehydrogense-1B and Aldehyde Dehydrogenase-2, Alcohol Flushing, Mean Corpuscular Volume, and Aerodigestive Tract Neoplasia in Japanese Drinkers
  17. Altmetric Badge
    Chapter 16 Acetaldehyde and Retinaldehyde-Metabolizing Enzymes in Colon and Pancreatic Cancers
  18. Altmetric Badge
    Chapter 17 Alcohol, Carcinoembryonic Antigen Processing and Colorectal Liver Metastases.
  19. Altmetric Badge
    Chapter 18 Alcohol Consumption and Antitumor Immunity: Dynamic Changes from Activation to Accelerated Deterioration of the Immune System.
  20. Altmetric Badge
    Chapter 19 A Perspective on Chemoprevention by Resveratrol in Head and Neck Squamous Cell Carcinoma
  21. Altmetric Badge
    Chapter 20 The Effects of Alcohol and Aldehyde Dehydrogenases on Disorders of Hematopoiesis
  22. Altmetric Badge
    Chapter 21 The Effect of Alcohol on Sirt1 Expression and Function in Animal and Human Models of Hepatocellular Carcinoma (HCC).
  23. Altmetric Badge
    Chapter 22 Transgenic mouse models for alcohol metabolism, toxicity, and cancer.
  24. Altmetric Badge
    Chapter 23 Fetal Alcohol Exposure Increases Susceptibility to Carcinogenesis and Promotes Tumor Progression in Prostate Gland
  25. Altmetric Badge
    Chapter 24 Fetal alcohol exposure and mammary tumorigenesis in offspring: role of the estrogen and insulin-like growth factor systems.
Attention for Chapter 5: Implications of Acetaldehyde-Derived DNA Adducts for Understanding Alcohol-Related Carcinogenesis.
Altmetric Badge

Mentioned by

twitter
1 X user

Citations

dimensions_citation
14 Dimensions

Readers on

mendeley
36 Mendeley
citeulike
1 CiteULike
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Chapter title
Implications of Acetaldehyde-Derived DNA Adducts for Understanding Alcohol-Related Carcinogenesis.
Chapter number 5
Book title
Biological Basis of Alcohol-Induced Cancer
Published in
Advances in experimental medicine and biology, January 2015
DOI 10.1007/978-3-319-09614-8_5
Pubmed ID
Book ISBNs
978-3-31-909613-1, 978-3-31-909614-8
Authors

Silvia Balbo, Philip J Brooks, Philip J. Brooks, Balbo, Silvia, Brooks, Philip J.

Abstract

Among various potential mechanisms that could explain alcohol carcinogenicity, the metabolism of ethanol to acetaldehyde represents an obvious possible mechanism, at least in some tissues. The fundamental principle of genotoxic carcinogenesis is the formation of mutagenic DNA adducts in proliferating cells. If not repaired, these adducts can result in mutations during DNA replication, which are passed on to cells during mitosis. Consistent with a genotoxic mechanism, acetaldehyde does react with DNA to form a variety of different types of DNA adducts. In this chapter we will focus more specifically on N (2)-ethylidene-deoxyguanosine (N2-ethylidene-dG), the major DNA adduct formed from the reaction of acetaldehyde with DNA and specifically highlight recent data on the measurement of this DNA adduct in the human body after alcohol exposure. Because results are of particular biological relevance for alcohol-related cancer of the upper aerodigestive tract (UADT), we will also discuss the histology and cytology of the UADT, with the goal of placing the adduct data in the relevant cellular context for mechanistic interpretation. Furthermore, we will discuss the sources and concentrations of acetaldehyde and ethanol in different cell types during alcohol consumption in humans. Finally, in the last part of the chapter, we will critically evaluate the concept of carcinogenic levels of acetaldehyde, which has been raised in the literature, and discuss how data from acetaldehyde genotoxicity are and can be utilized in physiologically based models to evaluate exposure risk.

X Demographics

X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 36 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 3%
Unknown 35 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 7 19%
Student > Bachelor 5 14%
Researcher 4 11%
Student > Master 2 6%
Professor 2 6%
Other 3 8%
Unknown 13 36%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 7 19%
Medicine and Dentistry 7 19%
Environmental Science 2 6%
Pharmacology, Toxicology and Pharmaceutical Science 1 3%
Nursing and Health Professions 1 3%
Other 3 8%
Unknown 15 42%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 November 2014.
All research outputs
#20,245,139
of 22,772,779 outputs
Outputs from Advances in experimental medicine and biology
#3,956
of 4,928 outputs
Outputs of similar age
#295,628
of 352,911 outputs
Outputs of similar age from Advances in experimental medicine and biology
#189
of 272 outputs
Altmetric has tracked 22,772,779 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 4,928 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.0. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 352,911 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 272 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.