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Mouse Retinal Phenotyping

Overview of attention for book
Cover of 'Mouse Retinal Phenotyping'

Table of Contents

  1. Altmetric Badge
    Book Overview
  2. Altmetric Badge
    Chapter 1 Morphological Survey from Neurons to Circuits of the Mouse Retina
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    Chapter 2 Measuring Retinal Function in the Mouse
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    Chapter 3 Modeling Retinal Diseases Using Genetic Approaches in Mice
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    Chapter 4 Cell Culture Analysis of the Phagocytosis of Photoreceptor Outer Segments by Primary Mouse RPE Cells
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    Chapter 5 Two-Photon Microscopy (TPM) and Fluorescence Lifetime Imaging Microscopy (FLIM) of Retinal Pigment Epithelium (RPE) of Mice In Vivo
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    Chapter 6 RPE Visual Cycle and Biochemical Phenotypes of Mutant Mouse Models
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    Chapter 7 Use of Direct Current Electroretinography for Analysis of Retinal Pigment Epithelium Function in Mouse Models
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    Chapter 8 Disruption of Rhodopsin Dimerization in Mouse Rod Photoreceptors by Synthetic Peptides Targeting Dimer Interface
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    Chapter 9 Experimental Approaches for Defining the Role of the Ca2+-Modulated ROS-GC System in Retinal Rods of Mouse
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    Chapter 10 Microglia Analysis in Retinal Degeneration Mouse Models
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    Chapter 11 Determination of Mitochondrial Oxygen Consumption in the Retina Ex Vivo: Applications for Retinal Disease
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    Chapter 12 Analysis of Feedback Signaling from Horizontal Cells to Photoreceptors in Mice
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    Chapter 13 Assessment of the Absolute Excitatory Level of the Retina by Flicker ERG
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    Chapter 14 Ex Vivo Functional Evaluation of Synaptic Transmission from Rods to Rod Bipolar Cells in Mice
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    Chapter 15 Functional and Morphological Analysis of OFF Bipolar Cells
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    Chapter 16 Immunohistochemical Phenotyping of Mouse Amacrine Cell Subtypes
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    Chapter 17 Phenotyping of Gap-Junctional Coupling in the Mouse Retina
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    Chapter 18 Ganglion Cell Assessment in Rodents with Retinal Degeneration
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    Chapter 19 Morphological Identification of Melanopsin-Expressing Retinal Ganglion Cell Subtypes in Mice
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    Chapter 20 Functional Assessment of Melanopsin-Driven Light Responses in the Mouse: Multielectrode Array Recordings
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    Chapter 21 In Vitro Assays for Mouse Müller Cell Phenotyping Through microRNA Profiling in the Damaged Retina
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    Chapter 22 Analysis of Retinal Vascular Plexuses and Interplexus Connections
Attention for Chapter 20: Functional Assessment of Melanopsin-Driven Light Responses in the Mouse: Multielectrode Array Recordings
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Chapter title
Functional Assessment of Melanopsin-Driven Light Responses in the Mouse: Multielectrode Array Recordings
Chapter number 20
Book title
Mouse Retinal Phenotyping
Published in
Methods in molecular biology, January 2018
DOI 10.1007/978-1-4939-7720-8_20
Pubmed ID
Book ISBNs
978-1-4939-7719-2, 978-1-4939-7720-8

Shi-Jun Weng, Jordan M. Renna, Wei-Yi Chen, Xiong-Li Yang


Intrinsically photosensitive retinal ganglion cells (ipRGCs) are a special subset of retinal output neurons capable of detecting and responding to light via a unique photopigment called melanopsin. Melanopsin activation is essential to a wide array of physiological functions, especially to those related to non-image-forming vision. Since ipRGCs only constitute a very small proportion of retinal ganglion cells, targeted recording of melanopsin-driven responses used to be a big challenge to vision researchers. Multielectrode array (MEA) recording provides a noninvasive, high throughput method to monitor melanopsin-driven responses. When synaptic inputs from rod/cone photoreceptors are silenced with glutamatergic blockers, extracellular electric signals derived from melanopsin activation can be recorded from multiple ipRGCs simultaneously by tens of microelectrodes aligned in an array. In this chapter we describe how our labs have approached MEA recording of melanopsin-driven light responses in adult mouse retinas. Instruments, tools and chemical reagents routinely used for setting up a successful MEA recording are listed, and a standard experimental procedure is provided. The implementation of this technique offers a useful paradigm that can be used to conduct functional assessments of ipRGCs and NIF vision.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 6 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 6 100%

Demographic breakdown

Readers by professional status Count As %
Unspecified 1 17%
Professor 1 17%
Researcher 1 17%
Other 1 17%
Student > Master 1 17%
Other 0 0%
Unknown 1 17%
Readers by discipline Count As %
Unspecified 1 17%
Mathematics 1 17%
Agricultural and Biological Sciences 1 17%
Immunology and Microbiology 1 17%
Medicine and Dentistry 1 17%
Other 0 0%
Unknown 1 17%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 March 2018.
All research outputs
of 21,190,873 outputs
Outputs from Methods in molecular biology
of 11,951 outputs
Outputs of similar age
of 298,160 outputs
Outputs of similar age from Methods in molecular biology
of 6 outputs
Altmetric has tracked 21,190,873 research outputs across all sources so far. This one is in the 33rd percentile – i.e., 33% of other outputs scored the same or lower than it.
So far Altmetric has tracked 11,951 research outputs from this source. They receive a mean Attention Score of 3.3. This one has gotten more attention than average, scoring higher than 61% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 298,160 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 37th percentile – i.e., 37% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 6 others from the same source and published within six weeks on either side of this one.