Chapter title |
Tie-1 receptor tyrosine kinase endodomain interaction with SHP2: potential signalling mechanisms and roles in angiogenesis.
|
---|---|
Chapter number | 3 |
Book title |
Angiogenesis
|
Published in |
Advances in experimental medicine and biology, January 2000
|
DOI | 10.1007/978-1-4615-4221-6_3 |
Pubmed ID | |
Book ISBNs |
978-1-4613-6895-3, 978-1-4615-4221-6
|
Authors |
M B Marron, D P Hughes, M J McCarthy, E R Beaumont, N P Brindle, Marron, Marrie B., Hughes, David P., McCarthy, Mark J., Brindle, Nicholas P. J., Beaumont, Eleanor R., Marrie B. Marron, David P. Hughes, Mark J. McCarthy, Nicholas P. J. Brindle, Eleanor R. Beaumont |
Abstract |
The endothelial receptor tyrosine kinase plays an essential role in vascular development where it is thought to be required for vessel maturation and stabilization. The ligands responsible for activating Tie-1, its signalling pathways and specific cellular functions are however not known. As with some other receptor tyrosine kinases, Tie-1 is subject to extracellular proteolytic cleavage generating a membrane bound receptor fragment comprising the intracellular and transmembrane domains. Here we examine the signalling potential of this Tie-1 endodomain. We show that the Tie-1 endodomain has poor ability to induce tyrosine phosphorylation. However, on formation the endodomain physically associates with a number of tyrosine phosphorylated signalling intermediates including the tyrosine phosphatase and adaptor protein SHP2. The assembly of this multimolecular complex is consistent with the endodomain having a ligand-independent signalling role in the endothelial cell. The potential roles of ectodomain cleavage and cleavage activated signalling in regulating microvessel stability in angiogenesis, vessel remodelling and regression are considered. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 14 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Professor > Associate Professor | 2 | 14% |
Researcher | 2 | 14% |
Student > Ph. D. Student | 2 | 14% |
Lecturer | 1 | 7% |
Student > Doctoral Student | 1 | 7% |
Other | 4 | 29% |
Unknown | 2 | 14% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 4 | 29% |
Agricultural and Biological Sciences | 4 | 29% |
Medicine and Dentistry | 3 | 21% |
Neuroscience | 1 | 7% |
Unknown | 2 | 14% |