A Systems Biology Approach to Advancing Adverse Outcome Pathways for Risk Assessment

Chapter 1 Advancing Adverse Outcome Pathways for Risk Assessment

Chapter 2 Use of High-Throughput and Computational Approaches for Endocrine Pathway Screening

Chapter 3 Cell-Free Assays in Environmental Toxicology

Chapter 4 The Fish Embryo as a Model for AOP Development

Chapter 5 Invertebrate Model Species in AOP Development

Chapter 6 Non-model Species in Ecological Risk Assessment

Chapter 7 Green Algae and Networks for Adverse Outcome Pathways

Chapter 8 Neurobehavioral Analysis Methods for Adverse Outcome Pathway (AOP) Models and Risk Assessment

Chapter 10 Use of Genetic Manipulation for Evaluating and Understanding Adverse Outcome Pathways

Chapter 11 Considering Epigenetics in Adverse Outcome Pathways

Chapter 12 Tiered Approaches to Incorporate the Adverse Outcome Pathway Framework into Chemical-Specific Risk-Based Decision Making

Chapter 13 The Development of Quantitative AOPs

Chapter 14 Linking Adverse Outcome Pathways to Dynamic Energy Budgets: A Conceptual Model

Chapter 15 Weight of Evidence Frameworks in Evaluation of Adverse Outcome Pathways

Chapter 16 Using a Vitellogenesis Model to Link in vitro Neurochemical Effects of Pulp and Paper Mill Effluents to Adverse Reproductive Outcomes in Fish

Chapter 17 Use of Adverse Outcome Pathways in Human Risk Assessment and Toxicology

Chapter 18 Use and Acceptance of AOPs for Regulatory Applications

Chapter 19 The Future of Adverse Outcome Pathways: Analyzing their Social Context