Chapter title |
Differential trace amine alterations in individuals receiving acetylenic inhibitors of MAO-A (clorgyline) or MAO-B (selegiline and pargyline).
|
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Chapter number | 5 |
Book title |
MAO — The Mother of all Amine Oxidases
|
Published in |
Journal of neural transmission Supplementum, January 1998
|
DOI | 10.1007/978-3-7091-6499-0_5 |
Pubmed ID | |
Book ISBNs |
978-3-21-183037-6, 978-3-70-916499-0
|
Authors |
D L Murphy, F Karoum, D Pickar, R M Cohen, S Lipper, A M Mellow, P N Tariot, T Sunderland, Murphy, D. L., Karoum, F., Pickar, D., Cohen, R. M., Lipper, S., Mellow, A. M., Tariot, P. N., Sunderland, T., D. L. Murphy, F. Karoum, D. Pickar, R. M. Cohen, S. Lipper, A. M. Mellow, P. N. Tariot, T. Sunderland |
Abstract |
Marked, dose-dependent elevations in the urinary excretion of phenylethylamine, para-tyramine, and meta-tyramine were observed in depressed patients treated for three or more weeks with 10, 30, or 60 mg/day of the partially-selective inhibitor of MAO-B, selegiline (l-deprenyl). In comparative studies with other, structurally similar acetylenic inhibitors of MAO, pargyline, an MAO-B > MAO-A inhibitor used in doses of 90 mg/day for three or more weeks, produced elevations in these trace amines which were similar to those found with the highest dose of selegiline studied. Clorgyline, a selective inhibitor of MAO-A used in doses of 30 mg/day for three or more weeks (a dose/time regimen previously reported to reduce urinary, plasma, and cerebrospinal fluid 3-methoxy-4-hydroxyphenylethyleneglycol (MHPG) > 80%, indicating a marked inhibitory effect on MAO-A in humans in vivo) produced negligible changes in trace amine excretion. In comparison to recent studies of individuals lacking the genes for MAO-A, MAO-B, or both MAO-A and MAO-B, the lack of change in trace amine excretion in individuals with a mutation affecting only MAO-A is in agreement with the observed lack of effect of clorgyline in the present study. Selegiline produced larger changes in trace amines--at least at the higher doses studied--than found in individuals lacking the gene for MAO-B, in agreement with other data suggesting a lesser selectivity for MAO-B inhibition when selegiline was given in doses higher than 10 mg/day. Overall, trace amine elevations in individuals receiving the highest dose of deprenyl or receiving pargyline were approximately three to five-fold lower than the elevations observed in individuals lacking the genes for both MAO-A and MAO-B, suggesting that these drug doses yield incomplete inhibition of MAO-A and MAO-B. |
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