Chapter title |
Antiviral Immune Responses by Human Langerhans Cells and Dendritic Cells in HIV-1 Infection.
|
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Chapter number | 2 |
Book title |
HIV Interactions with Dendritic Cells
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Published in |
Advances in experimental medicine and biology, February 2016
|
DOI | 10.1007/978-1-4614-4433-6_2 |
Pubmed ID | |
Book ISBNs |
978-1-4614-4432-9, 978-1-4614-4433-6
|
Authors |
Linda M. van den Berg, Teunis B. H. Geijtenbeek, van den Berg LM, Geijtenbeek TB, Berg, Linda M. van den, Geijtenbeek, Teunis B. H., van den Berg, Linda M. |
Abstract |
The main route of human immunodeficiency virus-1 (HIV-1) infection is via unprotected sexual intercourse, and therefore, vaginal tissues and male foreskin are viral entry sites. Langerhans cells (LCs) and dendritic cells (DCs) are amongst the first immune cells encountering HIV-1 since these cells line these mucosal tissues. Both LCs and DCs are equipped with specific pattern recognition receptors that not only sense pathogens, but induce specific immune responses against these pathogens. LCs express the C-type lectin receptor langerin, which provides protection against HIV-1 infection. In contrast, DCs express the C-type lectin receptor DC-SIGN, which facilitates capture as well as infection of DCs and subsequent transmission to CD4(+) T cells. This chapter gives an update on immune responses elicited against viruses and sheds a light on different immune mechanisms that are hijacked by HIV-1 to infect the host. HIV-1 infection ultimately leads to the worldwide pandemic acquired immunodeficiency syndrome (AIDS). |
X Demographics
Geographical breakdown
Country | Count | As % |
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Canada | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Scientists | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 14 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 4 | 29% |
Student > Master | 2 | 14% |
Lecturer | 1 | 7% |
Professor | 1 | 7% |
Unknown | 6 | 43% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 3 | 21% |
Agricultural and Biological Sciences | 2 | 14% |
Immunology and Microbiology | 1 | 7% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 7% |
Unknown | 7 | 50% |