Chapter title |
A proline-rich polypeptide from ovine colostrum: colostrinin with immunomodulatory activity.
|
---|---|
Chapter number | 9 |
Book title |
Bioactive Components of Milk
|
Published in |
Advances in experimental medicine and biology, February 2016
|
DOI | 10.1007/978-0-387-74087-4_9 |
Pubmed ID | |
Book ISBNs |
978-0-387-74086-7, 978-0-387-74087-4
|
Authors |
Michal Zimecki, Zimecki M, Zimecki, Michal |
Abstract |
A proline-rich polypeptide (PRP), later called colostrinin (CLN), was originally found as a fraction accompanying sheep colostral immunoglobulins. Extensive in vitro and in vivo studies in mice revealed its interesting T cell-tropic activities. The polypeptide promoted T cell maturation from early thymic precursors that acquired the phenotype and function of mature, helper cells; on the other hand, it also affected the phenotype and function of mature T cells. In particular, PRP was shown to recruit suppressor T cells in a model of T cell-independent humoral immune response and suppressed autoimmune hemolytic anemia in New Zealand Black mice. Subsequent in vitro studies in the human model revealed that CLN regulated mitogen-induced cytokine production in whole blood cultures. A discovery that CLN promoted procognitive functions in experimental animal models, supported by other laboratory findings, indicating prevention of pathological processes in the central nervous system, led to application of CLN in multicenter clinical trials. The trials demonstrated the therapeutic benefit of CLN in Alzheimer's disease (AD) patients by delaying progress of the disease. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Brazil | 1 | 4% |
Unknown | 23 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Other | 3 | 13% |
Student > Bachelor | 3 | 13% |
Researcher | 3 | 13% |
Professor > Associate Professor | 2 | 8% |
Student > Ph. D. Student | 2 | 8% |
Other | 4 | 17% |
Unknown | 7 | 29% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 5 | 21% |
Biochemistry, Genetics and Molecular Biology | 2 | 8% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 8% |
Medicine and Dentistry | 2 | 8% |
Chemistry | 2 | 8% |
Other | 4 | 17% |
Unknown | 7 | 29% |