Chapter title |
Clostridium difficile Biofilm
|
---|---|
Chapter number | 7 |
Book title |
Updates on Clostridium difficile in Europe
|
Published in |
Advances in experimental medicine and biology, January 2018
|
DOI | 10.1007/978-3-319-72799-8_7 |
Pubmed ID | |
Book ISBNs |
978-3-31-972798-1, 978-3-31-972799-8
|
Authors |
Claudia Vuotto, Gianfranco Donelli, Anthony Buckley, Caroline Chilton, Vuotto, Claudia, Donelli, Gianfranco, Buckley, Anthony, Chilton, Caroline |
Abstract |
Clostridium difficile infection (CDI) is an important healthcare-associated disease worldwide, mainly occurring after antimicrobial therapy. Antibiotics administered to treat a number of infections can promote C. difficile colonization of the gastrointestinal tract and, thus, CDI. A rise in multidrug resistant clinical isolates to multiple antibiotics and their reduced susceptibility to the most commonly used antibiotic molecules have made the treatment of CDI more complicated, allowing the persistence of C. difficile in the intestinal environment.Gut colonization and biofilm formation have been suggested to contribute to the pathogenesis and persistence of C. difficile. In fact, biofilm growth is considered as a serious threat because of the related increase in bacterial resistance that makes antibiotic therapy often ineffective. However, although the involvement of the C. difficile biofilm in the pathogenesis and recurrence of CDI is attracting more and more interest, the mechanisms underlying biofilm formation of C. difficile as well as the role of biofilm in CDI have not been extensively described.Findings on C. difficile biofilm, possible implications in CDI pathogenesis and treatment, efficacy of currently available antibiotics in treating biofilm-forming C. difficile strains, and some antimicrobial alternatives under investigation will be discussed here. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 2 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 50% |
Practitioners (doctors, other healthcare professionals) | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 86 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 14 | 16% |
Researcher | 9 | 10% |
Student > Master | 8 | 9% |
Other | 7 | 8% |
Student > Bachelor | 4 | 5% |
Other | 11 | 13% |
Unknown | 33 | 38% |
Readers by discipline | Count | As % |
---|---|---|
Immunology and Microbiology | 14 | 16% |
Biochemistry, Genetics and Molecular Biology | 12 | 14% |
Medicine and Dentistry | 8 | 9% |
Agricultural and Biological Sciences | 7 | 8% |
Nursing and Health Professions | 2 | 2% |
Other | 7 | 8% |
Unknown | 36 | 42% |