Chapter title |
Modulation of atherogenesis by dietary gamma-linolenic acid.
|
---|---|
Chapter number | 71 |
Book title |
Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation, and Radiation Injury, 4
|
Published in |
Advances in experimental medicine and biology, January 1999
|
DOI | 10.1007/978-1-4615-4793-8_71 |
Pubmed ID | |
Book ISBNs |
978-1-4613-7171-7, 978-1-4615-4793-8
|
Authors |
Fan, Y Y, Ramos, K S, Chapkin, R S, Fan, Yang-Yi, Ramos, Kenneth S., Chapkin, Robert S. |
Abstract |
Data from our in vitro studies indicate that macrophages isolated from mice fed GLA-enriched diets inhibit vascular SMC proliferation via a PGE1-cAMP dependent mechanism. Since SMC proliferation is one of the main events implicated in the pathogenesis of atherosclerosis (Ross, 1993), this anti-proliferative effect observed by dietary GLA is noteworthy. In vivo studies have established that dietary GLA is capable of retarding the atherosclerotic lesion formation in ApoE knock out mice, an animal model that develops atherosclerosis similar to humans (Reddick, 1994). We propose that dietary GLA has the potential to inhibit SMC proliferation leading to retardation of atherosclerotic lesion formation, and therefore favorable modulation of the atherogenic process. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Netherlands | 1 | 13% |
Unknown | 7 | 88% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Professor > Associate Professor | 2 | 25% |
Professor | 1 | 13% |
Unspecified | 1 | 13% |
Student > Ph. D. Student | 1 | 13% |
Other | 1 | 13% |
Other | 0 | 0% |
Unknown | 2 | 25% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 2 | 25% |
Agricultural and Biological Sciences | 1 | 13% |
Unspecified | 1 | 13% |
Unknown | 4 | 50% |