| Chapter title |
The role of the HBV envelope proteins in the HDV replication cycle.
|
|---|---|
| Chapter number | 6 |
| Book title |
Hepatitis Delta Virus
|
| Published in |
Current topics in microbiology and immunology, August 2006
|
| DOI | 10.1007/3-540-29802-9_6 |
| Pubmed ID | |
| Book ISBNs |
978-3-54-029801-4, 978-3-54-029802-1
|
| Authors |
Sureau C, Sureau, C., C. Sureau |
| Abstract |
The hepatitis delta virus (HDV) is a subviral agent that utilizes the envelope proteins of the hepatitis B virus (HBV) for propagation. When introduced into permissive cells, the HDV RNA genome replicates and associates with multiple copies of the HDV-encoded proteins to assemble a ribonucleoprotein (RNP) complex. The mechanism necessary to export the RNP from the cell is provided by the HBV envelope proteins, which have the capacity to assemble lipoprotein vesicles that bud into the lumen of a pre-Golgi compartment before being secreted. In addition to allowing the release of the HDV RNP, the HBV envelope proteins also provide a means for its targeting to an uninfected cell, thereby ensuring the spread of HDV. This chapter covers the molecular aspects of the HBV envelope protein functions in the HDV replication cycle, in particular the activity of the small envelope protein in RNP export and the function of the large envelope protein at viral entry. |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Oman | 1 | 3% |
| Unknown | 36 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 8 | 22% |
| Researcher | 7 | 19% |
| Student > Ph. D. Student | 5 | 14% |
| Student > Doctoral Student | 1 | 3% |
| Student > Bachelor | 1 | 3% |
| Other | 5 | 14% |
| Unknown | 10 | 27% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 8 | 22% |
| Biochemistry, Genetics and Molecular Biology | 7 | 19% |
| Immunology and Microbiology | 4 | 11% |
| Medicine and Dentistry | 3 | 8% |
| Nursing and Health Professions | 1 | 3% |
| Other | 3 | 8% |
| Unknown | 11 | 30% |