Chapter title |
Molecular Magnetic Resonance Imaging (mMRI)
|
---|---|
Chapter number | 19 |
Book title |
Preclinical MRI
|
Published in |
Methods in molecular biology, January 2018
|
DOI | 10.1007/978-1-4939-7531-0_19 |
Pubmed ID | |
Book ISBNs |
978-1-4939-7530-3, 978-1-4939-7531-0
|
Authors |
Maxime Gauberti, Antoine P. Fournier, Denis Vivien, Sara Martinez de Lizarrondo, Gauberti, Maxime, Fournier, Antoine P., Vivien, Denis, Martinez de Lizarrondo, Sara |
Abstract |
Molecular magnetic resonance imaging (mMRI) enables the detection of a protein of interest in vivo, in a noninvasive manner. The general concept of mMRI is to target a contrast agent to a protein of interest, and to perform a contrast-sensitive MRI sequence. Typically, contrast agents are made of a "contrastophore" (the part of the construct responsible for the contrast on the images) and a targeting moiety ("pharmacophore"). Recently, the development of a new family of contrastophore carrying a high payload of iron oxide (micro-sized particles of iron oxide, MPIO) has led to a dramatic increase in the sensitivity of mMRI. Here, we describe the production of targeted MPIO using commercially available reagents and the MRI protocols to allow their detection in vivo. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Russia | 1 | 3% |
Brazil | 1 | 3% |
Unknown | 34 | 94% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 9 | 25% |
Student > Master | 8 | 22% |
Researcher | 6 | 17% |
Student > Bachelor | 3 | 8% |
Student > Doctoral Student | 2 | 6% |
Other | 4 | 11% |
Unknown | 4 | 11% |
Readers by discipline | Count | As % |
---|---|---|
Chemistry | 8 | 22% |
Neuroscience | 7 | 19% |
Medicine and Dentistry | 7 | 19% |
Agricultural and Biological Sciences | 4 | 11% |
Engineering | 2 | 6% |
Other | 2 | 6% |
Unknown | 6 | 17% |