Chapter title |
Molecular Control of HIV and SIV Latency
|
---|---|
Chapter number | 74 |
Book title |
HIV-1 Latency
|
Published in |
Current topics in microbiology and immunology, January 2017
|
DOI | 10.1007/82_2017_74 |
Pubmed ID | |
Book ISBNs |
978-3-03-002815-2, 978-3-03-002816-9
|
Authors |
DARCIS, Gilles, Van Driessche, Benoit, Bouchat, Sophie, Kirchhoff, Frank, Van Lint, Carine, Gilles Darcis, Benoit Van Driessche, Sophie Bouchat, Frank Kirchhoff, Carine Van Lint, Darcis, Gilles |
Abstract |
The HIV latent reservoirs are considered as the main hurdle to viral eradication. Numerous mechanisms lead to the establishment of HIV latency and act at the transcriptional and post-transcriptional levels. A better understanding of latency is needed in order to ultimately achieve a cure for HIV. The mechanisms underlying latency vary between patients, tissues, anatomical compartments, and cell types. From this point of view, simian immunodeficiency virus (SIV) infection and the use of nonhuman primate (NHP) models that recapitulate many aspects of HIV-associated latency establishment and disease progression are essential tools since they allow extensive tissue sampling as well as a control of infection parameters (virus type, dose, route, and time). |
X Demographics
Geographical breakdown
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France | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 23 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Master | 5 | 22% |
Student > Ph. D. Student | 4 | 17% |
Student > Bachelor | 3 | 13% |
Researcher | 2 | 9% |
Student > Postgraduate | 2 | 9% |
Other | 0 | 0% |
Unknown | 7 | 30% |
Readers by discipline | Count | As % |
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Agricultural and Biological Sciences | 5 | 22% |
Biochemistry, Genetics and Molecular Biology | 3 | 13% |
Immunology and Microbiology | 3 | 13% |
Medicine and Dentistry | 2 | 9% |
Sports and Recreations | 1 | 4% |
Other | 2 | 9% |
Unknown | 7 | 30% |