| Chapter title |
Role of uric acid in multiple sclerosis.
|
|---|---|
| Chapter number | 13 |
| Book title |
Advances in multiple Sclerosis and Experimental Demyelinating Diseases
|
| Published in |
Current topics in microbiology and immunology, January 2008
|
| DOI | 10.1007/978-3-540-73677-6_13 |
| Pubmed ID | |
| Book ISBNs |
978-3-54-073676-9, 978-3-54-073677-6
|
| Authors |
Spitsin S, Koprowski H, S. Spitsin, H. Koprowski, Spitsin, S., Koprowski, H. |
| Abstract |
In the past decade, a growing number of evidence has implicated free radicals in a variety of pathophysiological conditions including aging, cancer, and coronary heart disease. Analyses of different aspects of multiple sclerosis (MS) pathology with respect to oxidative damage have also revealed evidence of free radical injury to the central nervous system (CNS), although attempts to protect the CNS using various antioxidants have met with only moderate success. Several recent studies have reported lower levels of uric acid (UA), a major scavenger of reactive nitrogen species, in MS patients, while other studies found no such correlation. Here, we discuss these studies as well as current efforts to manipulate serum UA levels in MS patients. |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 3% |
| Spain | 1 | 3% |
| Unknown | 31 | 94% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 6 | 18% |
| Other | 4 | 12% |
| Student > Ph. D. Student | 4 | 12% |
| Professor > Associate Professor | 4 | 12% |
| Student > Master | 4 | 12% |
| Other | 7 | 21% |
| Unknown | 4 | 12% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 7 | 21% |
| Engineering | 5 | 15% |
| Agricultural and Biological Sciences | 4 | 12% |
| Psychology | 2 | 6% |
| Biochemistry, Genetics and Molecular Biology | 2 | 6% |
| Other | 8 | 24% |
| Unknown | 5 | 15% |