Chapter title |
Construction and Use of Staphylococcus aureus Strains to Study Within-Host Infection Dynamics
|
---|---|
Chapter number | 2 |
Book title |
Antibiotic Resistance Protocols
|
Published in |
Methods in molecular biology, January 2018
|
DOI | 10.1007/978-1-4939-7638-6_2 |
Pubmed ID | |
Book ISBNs |
978-1-4939-7636-2, 978-1-4939-7638-6
|
Authors |
Gareth McVicker, Tomasz K. Prajsnar, Simon J. Foster, McVicker, Gareth, Prajsnar, Tomasz K., Foster, Simon J. |
Abstract |
The study of the dynamics that occur during the course of a bacterial infection has been attempted using several methods. Here we discuss the construction of a set of antibiotic-resistant, otherwise-isogenic Staphylococcus aureus strains that can be used to observe the progress of systemic disease in a mouse model at various time-points postinfection. The strains can likewise be used to study the progression of infection in other animal infection models, such as the zebrafish embryo. Furthermore, the use of antibiotic resistance tags provides a convenient system with which to investigate the effect of antimicrobial chemotherapy during disease. |
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France | 2 | 100% |
Demographic breakdown
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
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Unknown | 14 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 4 | 29% |
Student > Doctoral Student | 2 | 14% |
Unspecified | 1 | 7% |
Student > Bachelor | 1 | 7% |
Lecturer | 1 | 7% |
Other | 2 | 14% |
Unknown | 3 | 21% |
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Biochemistry, Genetics and Molecular Biology | 4 | 29% |
Unspecified | 1 | 7% |
Agricultural and Biological Sciences | 1 | 7% |
Medicine and Dentistry | 1 | 7% |
Other | 0 | 0% |
Unknown | 3 | 21% |