| Chapter title |
Manganese in Health and Disease
|
|---|---|
| Chapter number | 7 |
| Book title |
Interrelations between Essential Metal Ions and Human Diseases
|
| Published in |
Metal ions in life sciences, November 2013
|
| DOI | 10.1007/978-94-007-7500-8_7 |
| Pubmed ID | |
| Book ISBNs |
978-9-40-077499-5, 978-9-40-077500-8
|
| Authors |
Daiana Silva Avila, Robson Luiz Puntel, Michael Aschner, Avila, Daiana Silva, Puntel, Robson Luiz, Aschner, Michael |
| Editors |
Astrid Sigel, Helmut Sigel, Roland K.O. Sigel |
| Abstract |
Manganese is an important metal for human health, being absolutely necessary for development, metabolism, and the antioxidant system. Nevertheless, excessive exposure or intake may lead to a condition known as manganism, a neurodegenerative disorder that causes dopaminergic neuronal death and parkinsonian-like symptoms. Hence, Mn has a paradoxal effect in animals, a Janus-faced metal. Extensive work has been carried out to understand Mn-induced neurotoxicity and to find an effective treatment. This review focuses on the requirement for Mn in human health as well as the diseases associated with excessive exposure to this metal. |
Mendeley readers
Geographical breakdown
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|---|---|---|
| Japan | 1 | <1% |
| India | 1 | <1% |
| Australia | 1 | <1% |
| Unknown | 297 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 42 | 14% |
| Student > Bachelor | 40 | 13% |
| Student > Master | 38 | 13% |
| Student > Ph. D. Student | 29 | 10% |
| Other | 12 | 4% |
| Other | 45 | 15% |
| Unknown | 94 | 31% |
| Readers by discipline | Count | As % |
|---|---|---|
| Chemistry | 39 | 13% |
| Agricultural and Biological Sciences | 31 | 10% |
| Biochemistry, Genetics and Molecular Biology | 23 | 8% |
| Medicine and Dentistry | 18 | 6% |
| Environmental Science | 11 | 4% |
| Other | 72 | 24% |
| Unknown | 106 | 35% |