Chapter title |
Phosphatidylinositol 4, 5 bisphosphate and the actin cytoskeleton.
|
---|---|
Chapter number | 6 |
Book title |
Phosphoinositides II: The Diverse Biological Functions
|
Published in |
Sub cellular biochemistry, March 2012
|
DOI | 10.1007/978-94-007-3015-1_6 |
Pubmed ID | |
Book ISBNs |
978-9-40-073014-4, 978-9-40-073015-1
|
Authors |
Zhang L, Mao YS, Janmey PA, Yin HL, Li Zhang, Yuntao S. Mao, Paul A. Janmey, Helen L. Yin, Zhang, Li, Mao, Yuntao S., Janmey, Paul A., Yin, Helen L. |
Abstract |
Dynamic changes in PM PIP(2) have been implicated in the regulation of many processes that are dependent on actin polymerization and remodeling. PIP(2) is synthesized primarily by the type I phosphatidylinositol 4 phosphate 5 kinases (PIP5Ks), and there are three major isoforms, called a, b and g. There is emerging evidence that these PIP5Ks have unique as well as overlapping functions. This review will focus on the isoform-specific roles of individual PIP5K as they relate to the regulation of the actin cytoskeleton. We will review recent advances that establish PIP(2) as a critical regulator of actin polymerization and cytoskeleton/membrane linkages, and show how binding of cytoskeletal proteins to membrane PIP(2) might alter lateral or transverse movement of lipids to affect raft formation or lipid asymmetry. The mechanisms for specifying localized increase in PIP(2) to regulate dynamic actin remodeling will also be discussed. |
X Demographics
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
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United Kingdom | 1 | 3% |
India | 1 | 3% |
Czechia | 1 | 3% |
Unknown | 37 | 93% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 13 | 33% |
Student > Ph. D. Student | 9 | 23% |
Student > Master | 6 | 15% |
Student > Doctoral Student | 4 | 10% |
Student > Bachelor | 2 | 5% |
Other | 2 | 5% |
Unknown | 4 | 10% |
Readers by discipline | Count | As % |
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Biochemistry, Genetics and Molecular Biology | 9 | 23% |
Chemistry | 3 | 8% |
Neuroscience | 3 | 8% |
Immunology and Microbiology | 2 | 5% |
Other | 8 | 20% |
Unknown | 4 | 10% |