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Mendeley readers
Attention Score in Context
| Chapter title |
Engineering THIOMABs for Site-Specific Conjugation of Thiol-Reactive Linkers.
|
|---|---|
| Chapter number | 11 |
| Book title |
Antibody-Drug Conjugates
|
| Published in |
Methods in molecular biology, August 2013
|
| DOI | 10.1007/978-1-62703-541-5_11 |
| Pubmed ID | |
| Book ISBNs |
978-1-62703-540-8, 978-1-62703-541-5
|
| Authors |
Bhakta S, Raab H, Junutula JR, Sunil Bhakta, Helga Raab, Jagath R. Junutula, Bhakta, Sunil, Raab, Helga, Junutula, Jagath R. |
| Abstract |
Antibody conjugates are used in many therapeutic and research applications and are generated by chemically linking a cysteine or lysine residue to potent chemotherapeutic drugs or other functional groups through a flexible linker. Recently, we have engineered THIOMABs (antibodies with engineered reactive cysteine residues) for site-specific conjugation and showed that these antibody conjugates display homogeneous labeling with optimal in vitro and in vivo characteristics. Here, we describe protocols for engineering, selection, and site-specific conjugation of THIOMABs with thiol-reactive linkers. |
Mendeley readers
The data shown below were compiled from readership statistics for 54 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 54 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 14 | 26% |
| Student > Master | 11 | 20% |
| Student > Ph. D. Student | 11 | 20% |
| Student > Bachelor | 3 | 6% |
| Student > Doctoral Student | 2 | 4% |
| Other | 5 | 9% |
| Unknown | 8 | 15% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 14 | 26% |
| Chemistry | 12 | 22% |
| Agricultural and Biological Sciences | 8 | 15% |
| Pharmacology, Toxicology and Pharmaceutical Science | 3 | 6% |
| Veterinary Science and Veterinary Medicine | 2 | 4% |
| Other | 5 | 9% |
| Unknown | 10 | 19% |
Attention Score in Context
This research output has an Altmetric Attention Score of 9. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 September 2022.
All research outputs
#3,648,288
of 23,426,104 outputs
Outputs from Methods in molecular biology
#868
of 13,324 outputs
Outputs of similar age
#31,127
of 198,935 outputs
Outputs of similar age from Methods in molecular biology
#7
of 56 outputs
Altmetric has tracked 23,426,104 research outputs across all sources so far. Compared to these this one has done well and is in the 84th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 13,324 research outputs from this source. They receive a mean Attention Score of 3.4. This one has done particularly well, scoring higher than 93% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 198,935 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 84% of its contemporaries.
We're also able to compare this research output to 56 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 87% of its contemporaries.