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Proteins and Proteomics of Leishmania and Trypanosoma

Overview of attention for book
Cover of 'Proteins and Proteomics of Leishmania and Trypanosoma'

Table of Contents

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    Book Overview
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    Chapter 1 Biology of human pathogenic trypanosomatids: epidemiology, lifecycle and ultrastructure.
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    Chapter 2 Selection of Molecular Targets for Drug Development Against Trypanosomatids
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    Chapter 3 A2 and Other Visceralizing Proteins of Leishmania : Role in Pathogenesis and Application for Vaccine Development
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    Chapter 4 Arginase in Leishmania.
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    Chapter 5 The Heat Shock Proteins of Trypanosoma cruzi
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    Chapter 6 The gp82 Surface Molecule of Trypanosoma cruzi Metacyclic Forms
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    Chapter 7 The Gp85 Surface Glycoproteins from Trypanosoma cruzi
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    Chapter 8 Trypanosoma cruzi Trans-Sialidase: Structural Features and Biological Implications.
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    Chapter 9 Surface topology evolution of trypanosoma trans-sialidase.
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    Chapter 10 Ecto-nucleotidases and Ecto-phosphatases from Leishmania and Trypanosoma Parasites
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    Chapter 11 GP63 Function in the Interaction of Trypanosomatids with the Invertebrate Host: Facts and Prospects
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    Chapter 12 Highlights on Trypanosomatid Aminoacyl-tRNA Synthesis
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    Chapter 13 The Expected Outcome of the Trypanosoma cruzi Proteomic Map: A Review of Its Potential Biological Applications for Drug Target Discovery
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    Chapter 14 Proteomics Advances in the Study of Leishmania Parasites and Leishmaniasis
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    Chapter 15 Towards the Phosphoproteome of Trypanosomatids
Attention for Chapter 8: Trypanosoma cruzi Trans-Sialidase: Structural Features and Biological Implications.
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Chapter title
Trypanosoma cruzi Trans-Sialidase: Structural Features and Biological Implications.
Chapter number 8
Book title
Proteins and Proteomics of Leishmania and Trypanosoma
Published in
Sub cellular biochemistry, November 2013
DOI 10.1007/978-94-007-7305-9_8
Pubmed ID
24264246
Book ISBNs
978-9-40-077304-2, 978-9-40-077305-9
Authors

Oliveira IA, Freire-de-Lima L, Penha LL, Dias WB, Todeschini AR, Isadora A. Oliveira, Leonardo Freire-de-Lima, Luciana L. Penha, Wagner B. Dias, Adriane R. Todeschini

Abstract

Trypanosoma cruzi trans-sialidase (TcTS) has intrigued researchers all over the world since it was shown that T. cruzi incorporates sialic acid through a mechanism independent of sialyltransferases. The enzyme has being involved in a vast myriad of functions in the biology of the parasite and in the pathology of Chagas' disease. At the structural level experiments trapping the intermediate with fluorosugars followed by peptide mapping, X-ray crystallography, molecular modeling and magnetic nuclear resonance have opened up a three-dimensional understanding of the way this enzyme works. Herein we review the multiple biological roles of TcTS and the structural studies that are slowly revealing the secrets underlining an efficient sugar transfer activity rather than simple hydrolysis by TcTS.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 29 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 29 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 5 17%
Student > Bachelor 4 14%
Student > Doctoral Student 3 10%
Professor > Associate Professor 3 10%
Other 2 7%
Other 5 17%
Unknown 7 24%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 7 24%
Agricultural and Biological Sciences 6 21%
Immunology and Microbiology 3 10%
Chemistry 2 7%
Medicine and Dentistry 1 3%
Other 1 3%
Unknown 9 31%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 January 2015.
All research outputs
#20,248,338
of 22,776,824 outputs
Outputs from Sub cellular biochemistry
#295
of 354 outputs
Outputs of similar age
#262,937
of 302,195 outputs
Outputs of similar age from Sub cellular biochemistry
#19
of 24 outputs
Altmetric has tracked 22,776,824 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 354 research outputs from this source. They receive a mean Attention Score of 4.7. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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We're also able to compare this research output to 24 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.

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