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Proteins and Proteomics of Leishmania and Trypanosoma

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Cover of 'Proteins and Proteomics of Leishmania and Trypanosoma'

Table of Contents

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    Book Overview
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    Chapter 1 Biology of human pathogenic trypanosomatids: epidemiology, lifecycle and ultrastructure.
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    Chapter 2 Selection of Molecular Targets for Drug Development Against Trypanosomatids
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    Chapter 3 A2 and Other Visceralizing Proteins of Leishmania : Role in Pathogenesis and Application for Vaccine Development
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    Chapter 4 Arginase in Leishmania.
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    Chapter 5 The Heat Shock Proteins of Trypanosoma cruzi
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    Chapter 6 The gp82 Surface Molecule of Trypanosoma cruzi Metacyclic Forms
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    Chapter 7 The Gp85 Surface Glycoproteins from Trypanosoma cruzi
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    Chapter 8 Trypanosoma cruzi Trans-Sialidase: Structural Features and Biological Implications.
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    Chapter 9 Surface topology evolution of trypanosoma trans-sialidase.
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    Chapter 10 Ecto-nucleotidases and Ecto-phosphatases from Leishmania and Trypanosoma Parasites
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    Chapter 11 GP63 Function in the Interaction of Trypanosomatids with the Invertebrate Host: Facts and Prospects
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    Chapter 12 Highlights on Trypanosomatid Aminoacyl-tRNA Synthesis
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    Chapter 13 The Expected Outcome of the Trypanosoma cruzi Proteomic Map: A Review of Its Potential Biological Applications for Drug Target Discovery
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    Chapter 14 Proteomics Advances in the Study of Leishmania Parasites and Leishmaniasis
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    Chapter 15 Towards the Phosphoproteome of Trypanosomatids
Attention for Chapter 9: Surface topology evolution of trypanosoma trans-sialidase.
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Chapter title
Surface topology evolution of trypanosoma trans-sialidase.
Chapter number 9
Book title
Proteins and Proteomics of Leishmania and Trypanosoma
Published in
Sub cellular biochemistry, November 2013
DOI 10.1007/978-94-007-7305-9_9
Pubmed ID
Book ISBNs
978-9-40-077304-2, 978-9-40-077305-9
Authors

De Celis SS, Sergio Steven Cornejo Rubin De Celis

Abstract

The trans-sialidase (TS) from Trypanosoma cruzi is a multifunctional protein given by its enzymatic activity and binding properties. The complex structure of TS promotes topology changes over the protozoa's surface with dramatic consequences for its biology. Detailed sequence analyses show that the evolution of TS in T. cruzi and other trypanosomes as well as its genomic organization is even more complex than it has been supposed before. All of these aspects are still neglected when TS is selected as a target for drug design and chemotherapy of Chagas' disease. Herein these aspects are discussed in the context of TS multifunctionality and dynamics drug design.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 3 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 3 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 1 33%
Professor > Associate Professor 1 33%
Unknown 1 33%
Readers by discipline Count As %
Agricultural and Biological Sciences 2 67%
Unknown 1 33%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 January 2015.
All research outputs
#20,248,338
of 22,776,824 outputs
Outputs from Sub cellular biochemistry
#295
of 354 outputs
Outputs of similar age
#262,937
of 302,195 outputs
Outputs of similar age from Sub cellular biochemistry
#19
of 24 outputs
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So far Altmetric has tracked 354 research outputs from this source. They receive a mean Attention Score of 4.7. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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