| Chapter title |
Plasticity of the Muscle Stem Cell Microenvironment
|
|---|---|
| Chapter number | 8 |
| Book title |
Stem Cell Microenvironments and Beyond
|
| Published in |
Advances in experimental medicine and biology, January 2017
|
| DOI | 10.1007/978-3-319-69194-7_8 |
| Pubmed ID | |
| Book ISBNs |
978-3-31-969193-0, 978-3-31-969194-7
|
| Authors |
Ivana Dinulovic, Regula Furrer, Christoph Handschin |
| Abstract |
Satellite cells (SCs) are adult muscle stem cells capable of repairing damaged and creating new muscle tissue throughout life. Their functionality is tightly controlled by a microenvironment composed of a wide variety of factors, such as numerous secreted molecules and different cell types, including blood vessels, oxygen, hormones, motor neurons, immune cells, cytokines, fibroblasts, growth factors, myofibers, myofiber metabolism, the extracellular matrix and tissue stiffness. This complex niche controls SC biology-quiescence, activation, proliferation, differentiation or renewal and return to quiescence. In this review, we attempt to give a brief overview of the most important players in the niche and their mutual interaction with SCs. We address the importance of the niche to SC behavior under physiological and pathological conditions, and finally survey the significance of an artificial niche both for basic and translational research purposes. |
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Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Switzerland | 1 | 33% |
| Unknown | 2 | 67% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 67% |
| Scientists | 1 | 33% |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 31 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 6 | 19% |
| Student > Bachelor | 5 | 16% |
| Student > Master | 4 | 13% |
| Researcher | 3 | 10% |
| Professor | 3 | 10% |
| Other | 7 | 23% |
| Unknown | 3 | 10% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 10 | 32% |
| Agricultural and Biological Sciences | 5 | 16% |
| Engineering | 5 | 16% |
| Chemical Engineering | 2 | 6% |
| Physics and Astronomy | 1 | 3% |
| Other | 3 | 10% |
| Unknown | 5 | 16% |